Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN): a part of osteomyelitis disease biology

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Standard

Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) : a part of osteomyelitis disease biology. / Jensen, Louise Kruse; Birch, Julie Melsted; Jensen, Henrik Elvang; Kirketerp-Møller, Klaus; Gottlieb, Hans.

In: APMIS, Vol. 131, No. 7, 2023, p. 325-332.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, LK, Birch, JM, Jensen, HE, Kirketerp-Møller, K & Gottlieb, H 2023, 'Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN): a part of osteomyelitis disease biology', APMIS, vol. 131, no. 7, pp. 325-332. https://doi.org/10.1111/apm.13312

APA

Jensen, L. K., Birch, J. M., Jensen, H. E., Kirketerp-Møller, K., & Gottlieb, H. (2023). Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN): a part of osteomyelitis disease biology. APMIS, 131(7), 325-332. https://doi.org/10.1111/apm.13312

Vancouver

Jensen LK, Birch JM, Jensen HE, Kirketerp-Møller K, Gottlieb H. Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN): a part of osteomyelitis disease biology. APMIS. 2023;131(7):325-332. https://doi.org/10.1111/apm.13312

Author

Jensen, Louise Kruse ; Birch, Julie Melsted ; Jensen, Henrik Elvang ; Kirketerp-Møller, Klaus ; Gottlieb, Hans. / Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) : a part of osteomyelitis disease biology. In: APMIS. 2023 ; Vol. 131, No. 7. pp. 325-332.

Bibtex

@article{2b3fe0ea530f4b388fc751adc8680e08,
title = "Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN): a part of osteomyelitis disease biology",
abstract = "Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.",
keywords = "Bacteriology, bone infections, histopathology, molecular microbiology, staphylococci",
author = "Jensen, {Louise Kruse} and Birch, {Julie Melsted} and Jensen, {Henrik Elvang} and Klaus Kirketerp-M{\o}ller and Hans Gottlieb",
note = "Funding Information: This study was financed by the Lundbeck Foundation (grant no. R‐345‐2020‐1674 to L.K.J.). ",
year = "2023",
doi = "10.1111/apm.13312",
language = "English",
volume = "131",
pages = "325--332",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "7",

}

RIS

TY - JOUR

T1 - Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN)

T2 - a part of osteomyelitis disease biology

AU - Jensen, Louise Kruse

AU - Birch, Julie Melsted

AU - Jensen, Henrik Elvang

AU - Kirketerp-Møller, Klaus

AU - Gottlieb, Hans

N1 - Funding Information: This study was financed by the Lundbeck Foundation (grant no. R‐345‐2020‐1674 to L.K.J.).

PY - 2023

Y1 - 2023

N2 - Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.

AB - Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.

KW - Bacteriology

KW - bone infections

KW - histopathology

KW - molecular microbiology

KW - staphylococci

U2 - 10.1111/apm.13312

DO - 10.1111/apm.13312

M3 - Journal article

C2 - 36951581

AN - SCOPUS:85159097020

VL - 131

SP - 325

EP - 332

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 7

ER -

ID: 359649835