Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs. / Obelitz-Ryom, Karina; Bering, Stine Brandt; Overgaard, Silja Hvid; Eskildsen, Simon Fristed; Ringgaard, Steffen; Olesen, Jonas Lynge; Skovgaard, Kerstin; Pankratova, Stanislava; Wang, Bing; Brunse, Anders; Heckmann, Anne Birgitte; Rydal, Martin Peter; Sangild, Per Torp; Thymann, Thomas.

In: Nutrients, Vol. 11, No. 6, 1335, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Obelitz-Ryom, K, Bering, SB, Overgaard, SH, Eskildsen, SF, Ringgaard, S, Olesen, JL, Skovgaard, K, Pankratova, S, Wang, B, Brunse, A, Heckmann, AB, Rydal, MP, Sangild, PT & Thymann, T 2019, 'Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs', Nutrients, vol. 11, no. 6, 1335. https://doi.org/10.3390/nu11061335

APA

Obelitz-Ryom, K., Bering, S. B., Overgaard, S. H., Eskildsen, S. F., Ringgaard, S., Olesen, J. L., Skovgaard, K., Pankratova, S., Wang, B., Brunse, A., Heckmann, A. B., Rydal, M. P., Sangild, P. T., & Thymann, T. (2019). Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs. Nutrients, 11(6), [1335]. https://doi.org/10.3390/nu11061335

Vancouver

Obelitz-Ryom K, Bering SB, Overgaard SH, Eskildsen SF, Ringgaard S, Olesen JL et al. Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs. Nutrients. 2019;11(6). 1335. https://doi.org/10.3390/nu11061335

Author

Obelitz-Ryom, Karina ; Bering, Stine Brandt ; Overgaard, Silja Hvid ; Eskildsen, Simon Fristed ; Ringgaard, Steffen ; Olesen, Jonas Lynge ; Skovgaard, Kerstin ; Pankratova, Stanislava ; Wang, Bing ; Brunse, Anders ; Heckmann, Anne Birgitte ; Rydal, Martin Peter ; Sangild, Per Torp ; Thymann, Thomas. / Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs. In: Nutrients. 2019 ; Vol. 11, No. 6.

Bibtex

@article{4780e4b1adf040608868c5f3a24ba30c,
title = "Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs",
abstract = "Optimal nutrition is important after preterm birth to facilitate normal brain development. Human milk is rich in sialic acid and preterm infants may benefit from supplementing formula with sialyllactose to support neurodevelopment. Using pigs as models, we hypothesized that sialyllactose supplementation improves brain development after preterm birth. Pigs (of either sex) were delivered by cesarean section at 90% gestation and fed a milk diet supplemented with either an oligosaccharide-enriched whey with sialyllactose (n = 20) or lactose (n = 20) for 19 days. Cognitive performance was tested in a spatial T-maze. Brains were collected for ex vivo magnetic resonance imaging (MRI), gene expression, and sialic acid measurements. For reference, term piglets (n = 14) were artificially reared under identical conditions and compared with vaginally born piglets naturally reared by the sow (n = 12). A higher proportion of sialyllactose supplemented preterm pigs reached the T-maze learning criteria relative to control preterm pigs (p < 0.05), and approximated the cognition level of term reference pigs (p < 0.01). Furthermore, supplemented pigs had upregulated genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in hippocampus. Sialyllactose supplementation did not lead to higher levels of sialic acid in the hippocampus or change MRI endpoints. Contrary, these parameters were strongly influenced by postconceptional age and postnatal rearing conditions. In conclusion, oligosaccharide-enriched whey with sialyllactose improved spatial cognition, with effects on hippocampal genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in preterm pigs. Dietary sialic acid enrichment may improve brain development in infants",
keywords = "sialic acid, cognition, brain, preterm birth, milk",
author = "Karina Obelitz-Ryom and Bering, {Stine Brandt} and Overgaard, {Silja Hvid} and Eskildsen, {Simon Fristed} and Steffen Ringgaard and Olesen, {Jonas Lynge} and Kerstin Skovgaard and Stanislava Pankratova and Bing Wang and Anders Brunse and Heckmann, {Anne Birgitte} and Rydal, {Martin Peter} and Sangild, {Per Torp} and Thomas Thymann",
year = "2019",
doi = "10.3390/nu11061335",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "6",

}

RIS

TY - JOUR

T1 - Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs

AU - Obelitz-Ryom, Karina

AU - Bering, Stine Brandt

AU - Overgaard, Silja Hvid

AU - Eskildsen, Simon Fristed

AU - Ringgaard, Steffen

AU - Olesen, Jonas Lynge

AU - Skovgaard, Kerstin

AU - Pankratova, Stanislava

AU - Wang, Bing

AU - Brunse, Anders

AU - Heckmann, Anne Birgitte

AU - Rydal, Martin Peter

AU - Sangild, Per Torp

AU - Thymann, Thomas

PY - 2019

Y1 - 2019

N2 - Optimal nutrition is important after preterm birth to facilitate normal brain development. Human milk is rich in sialic acid and preterm infants may benefit from supplementing formula with sialyllactose to support neurodevelopment. Using pigs as models, we hypothesized that sialyllactose supplementation improves brain development after preterm birth. Pigs (of either sex) were delivered by cesarean section at 90% gestation and fed a milk diet supplemented with either an oligosaccharide-enriched whey with sialyllactose (n = 20) or lactose (n = 20) for 19 days. Cognitive performance was tested in a spatial T-maze. Brains were collected for ex vivo magnetic resonance imaging (MRI), gene expression, and sialic acid measurements. For reference, term piglets (n = 14) were artificially reared under identical conditions and compared with vaginally born piglets naturally reared by the sow (n = 12). A higher proportion of sialyllactose supplemented preterm pigs reached the T-maze learning criteria relative to control preterm pigs (p < 0.05), and approximated the cognition level of term reference pigs (p < 0.01). Furthermore, supplemented pigs had upregulated genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in hippocampus. Sialyllactose supplementation did not lead to higher levels of sialic acid in the hippocampus or change MRI endpoints. Contrary, these parameters were strongly influenced by postconceptional age and postnatal rearing conditions. In conclusion, oligosaccharide-enriched whey with sialyllactose improved spatial cognition, with effects on hippocampal genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in preterm pigs. Dietary sialic acid enrichment may improve brain development in infants

AB - Optimal nutrition is important after preterm birth to facilitate normal brain development. Human milk is rich in sialic acid and preterm infants may benefit from supplementing formula with sialyllactose to support neurodevelopment. Using pigs as models, we hypothesized that sialyllactose supplementation improves brain development after preterm birth. Pigs (of either sex) were delivered by cesarean section at 90% gestation and fed a milk diet supplemented with either an oligosaccharide-enriched whey with sialyllactose (n = 20) or lactose (n = 20) for 19 days. Cognitive performance was tested in a spatial T-maze. Brains were collected for ex vivo magnetic resonance imaging (MRI), gene expression, and sialic acid measurements. For reference, term piglets (n = 14) were artificially reared under identical conditions and compared with vaginally born piglets naturally reared by the sow (n = 12). A higher proportion of sialyllactose supplemented preterm pigs reached the T-maze learning criteria relative to control preterm pigs (p < 0.05), and approximated the cognition level of term reference pigs (p < 0.01). Furthermore, supplemented pigs had upregulated genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in hippocampus. Sialyllactose supplementation did not lead to higher levels of sialic acid in the hippocampus or change MRI endpoints. Contrary, these parameters were strongly influenced by postconceptional age and postnatal rearing conditions. In conclusion, oligosaccharide-enriched whey with sialyllactose improved spatial cognition, with effects on hippocampal genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in preterm pigs. Dietary sialic acid enrichment may improve brain development in infants

KW - sialic acid

KW - cognition

KW - brain

KW - preterm birth

KW - milk

U2 - 10.3390/nu11061335

DO - 10.3390/nu11061335

M3 - Journal article

C2 - 31207876

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 6

M1 - 1335

ER -

ID: 225376107