Complexity of Sex Differences and Their Impact on Alzheimer’s Disease

Research output: Contribution to journal › Review › Research › peer-review

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Complexity of Sex Differences and Their Impact on Alzheimer’s Disease. / Kadlecová, Marion; Freude, Kristine; Haukedal, Henriette.

In: Biomedicines, Vol. 11, No. 5, 1261, 24.04.2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Kadlecová, M, Freude, K & Haukedal, H 2023, 'Complexity of Sex Differences and Their Impact on Alzheimer’s Disease', Biomedicines, vol. 11, no. 5, 1261. https://doi.org/10.3390/biomedicines11051261

APA

Kadlecová, M., Freude, K., & Haukedal, H. (2023). Complexity of Sex Differences and Their Impact on Alzheimer’s Disease. Biomedicines, 11(5), [1261]. https://doi.org/10.3390/biomedicines11051261

Vancouver

Kadlecová M, Freude K, Haukedal H. Complexity of Sex Differences and Their Impact on Alzheimer’s Disease. Biomedicines. 2023 Apr 24;11(5). 1261. https://doi.org/10.3390/biomedicines11051261

Author

Kadlecová, Marion ; Freude, Kristine ; Haukedal, Henriette. / Complexity of Sex Differences and Their Impact on Alzheimer’s Disease. In: Biomedicines. 2023 ; Vol. 11, No. 5.

Bibtex

@article{268b3ecac9354569963f7a48eb0e1a49,
title = "Complexity of Sex Differences and Their Impact on Alzheimer{\textquoteright}s Disease",
abstract = "Sex differences are present in brain morphology, sex hormones, aging processes and immune responses. These differences need to be considered for proper modelling of neurological diseases with clear sex differences. This is the case for Alzheimer{\textquoteright}s disease (AD), a fatal neurodegenerative disorder with two-thirds of cases diagnosed in women. It is becoming clear that there is a complex interplay between the immune system, sex hormones and AD. Microglia are major players in the neuroinflammatory process occurring in AD and have been shown to be directly affected by sex hormones. However, many unanswered questions remain as the importance of including both sexes in research studies has only recently started receiving attention. In this review, we provide a summary of sex differences and their implications in AD, with a focus on microglia action. Furthermore, we discuss current available study models, including emerging complex microfluidic and 3D cellular models and their usefulness for studying hormonal effects in this disease.",
author = "Marion Kadlecov{\'a} and Kristine Freude and Henriette Haukedal",
year = "2023",
month = apr,
day = "24",
doi = "10.3390/biomedicines11051261",
language = "English",
volume = "11",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Complexity of Sex Differences and Their Impact on Alzheimer’s Disease

AU - Kadlecová, Marion

AU - Freude, Kristine

AU - Haukedal, Henriette

PY - 2023/4/24

Y1 - 2023/4/24

N2 - Sex differences are present in brain morphology, sex hormones, aging processes and immune responses. These differences need to be considered for proper modelling of neurological diseases with clear sex differences. This is the case for Alzheimer’s disease (AD), a fatal neurodegenerative disorder with two-thirds of cases diagnosed in women. It is becoming clear that there is a complex interplay between the immune system, sex hormones and AD. Microglia are major players in the neuroinflammatory process occurring in AD and have been shown to be directly affected by sex hormones. However, many unanswered questions remain as the importance of including both sexes in research studies has only recently started receiving attention. In this review, we provide a summary of sex differences and their implications in AD, with a focus on microglia action. Furthermore, we discuss current available study models, including emerging complex microfluidic and 3D cellular models and their usefulness for studying hormonal effects in this disease.

AB - Sex differences are present in brain morphology, sex hormones, aging processes and immune responses. These differences need to be considered for proper modelling of neurological diseases with clear sex differences. This is the case for Alzheimer’s disease (AD), a fatal neurodegenerative disorder with two-thirds of cases diagnosed in women. It is becoming clear that there is a complex interplay between the immune system, sex hormones and AD. Microglia are major players in the neuroinflammatory process occurring in AD and have been shown to be directly affected by sex hormones. However, many unanswered questions remain as the importance of including both sexes in research studies has only recently started receiving attention. In this review, we provide a summary of sex differences and their implications in AD, with a focus on microglia action. Furthermore, we discuss current available study models, including emerging complex microfluidic and 3D cellular models and their usefulness for studying hormonal effects in this disease.

U2 - 10.3390/biomedicines11051261

DO - 10.3390/biomedicines11051261

M3 - Review

C2 - 37238932

VL - 11

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 5

M1 - 1261

ER -

ID: 344669468