Evaluation of Fluorescent Light Energy for the Treatment of Acute Second-degree Burns
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Evaluation of Fluorescent Light Energy for the Treatment of Acute Second-degree Burns. / Mellergaard, Maiken; Fauverghe, Stéphane; Scarpa, Carlotta; Pozner, Vladimir Luca; Skov, Søren; Hebert, Lise; Nielsen, Michael; Bassetto, Franco; Téot, Luc.
In: Military Medicine, Vol. 186, No. Suppl 1, 2021, p. 416-423.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evaluation of Fluorescent Light Energy for the Treatment of Acute Second-degree Burns
AU - Mellergaard, Maiken
AU - Fauverghe, Stéphane
AU - Scarpa, Carlotta
AU - Pozner, Vladimir Luca
AU - Skov, Søren
AU - Hebert, Lise
AU - Nielsen, Michael
AU - Bassetto, Franco
AU - Téot, Luc
N1 - © The Association of Military Surgeons of the United States 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2021
Y1 - 2021
N2 - INTRODUCTION: The use of photobiomodulation has been proposed to improve wound healing for the last two decades. Recent development in photobiomodulation has led to the development of a novel biophotonic platform that utilizes fluorescent light energy (FLE) within the visible spectrum of light for healing of skin inflammation and wounds.MATERIALS AND METHODS: In this article, FLE was used in preliminary analysis on 18 case studies of acute second-degree burns and in a pilot study using an ex vivo human skin model. Efficacy of FLE on wound healing and tissue remodeling was evaluated by monitoring improvements in the treated tissues, assessing pain for the patients, and by performing human genome microarray analysis of FLE-treated human skin samples.RESULTS: Healing was reported for all 18 patients treated with FLE for acute second-degree burns without reported adverse effects or development of infections. Furthermore, preliminary ex vivo skin model data suggest that FLE impacts different cellular pathways including essential immune-modulatory mechanisms.CONCLUSIONS: The results presented in this article are encouraging and suggest that FLE balances different stages of wound healing, which opens the door to initiating randomized controlled clinical trials for establishing the efficacy of FLE treatment in different phases of wound healing of second-degree burns.
AB - INTRODUCTION: The use of photobiomodulation has been proposed to improve wound healing for the last two decades. Recent development in photobiomodulation has led to the development of a novel biophotonic platform that utilizes fluorescent light energy (FLE) within the visible spectrum of light for healing of skin inflammation and wounds.MATERIALS AND METHODS: In this article, FLE was used in preliminary analysis on 18 case studies of acute second-degree burns and in a pilot study using an ex vivo human skin model. Efficacy of FLE on wound healing and tissue remodeling was evaluated by monitoring improvements in the treated tissues, assessing pain for the patients, and by performing human genome microarray analysis of FLE-treated human skin samples.RESULTS: Healing was reported for all 18 patients treated with FLE for acute second-degree burns without reported adverse effects or development of infections. Furthermore, preliminary ex vivo skin model data suggest that FLE impacts different cellular pathways including essential immune-modulatory mechanisms.CONCLUSIONS: The results presented in this article are encouraging and suggest that FLE balances different stages of wound healing, which opens the door to initiating randomized controlled clinical trials for establishing the efficacy of FLE treatment in different phases of wound healing of second-degree burns.
U2 - 10.1093/milmed/usaa299
DO - 10.1093/milmed/usaa299
M3 - Journal article
C2 - 33499452
VL - 186
SP - 416
EP - 423
JO - Military Medicine
JF - Military Medicine
SN - 0026-4075
IS - Suppl 1
ER -
ID: 256315646