Evidence for nucleolar dysfunction in Alzheimer's disease

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Evidence for nucleolar dysfunction in Alzheimer's disease. / Nyhus, Caitlin ; Pihl, Maria ; Hyttel, Poul; Hall, Vanessa Jane.

In: Reviews in the Neurosciences, Vol. 30, No. 7, 2019, p. 685–700.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Nyhus, C, Pihl, M, Hyttel, P & Hall, VJ 2019, 'Evidence for nucleolar dysfunction in Alzheimer's disease', Reviews in the Neurosciences, vol. 30, no. 7, pp. 685–700. https://doi.org/10.1515/revneuro-2018-0104

APA

Nyhus, C., Pihl, M., Hyttel, P., & Hall, V. J. (2019). Evidence for nucleolar dysfunction in Alzheimer's disease. Reviews in the Neurosciences, 30(7), 685–700. https://doi.org/10.1515/revneuro-2018-0104

Vancouver

Nyhus C, Pihl M, Hyttel P, Hall VJ. Evidence for nucleolar dysfunction in Alzheimer's disease. Reviews in the Neurosciences. 2019;30(7):685–700. https://doi.org/10.1515/revneuro-2018-0104

Author

Nyhus, Caitlin ; Pihl, Maria ; Hyttel, Poul ; Hall, Vanessa Jane. / Evidence for nucleolar dysfunction in Alzheimer's disease. In: Reviews in the Neurosciences. 2019 ; Vol. 30, No. 7. pp. 685–700.

Bibtex

@article{476aba6a16a744daaa768470e2e7ade5,
title = "Evidence for nucleolar dysfunction in Alzheimer's disease",
abstract = "The nucleolus is a dynamically changing organelle that is central to a number of important cellular functions. Not only is it important for ribosome biogenesis, but it also reacts to stress by instigating a nucleolar stress response and is further involved in regulating the cell cycle. Several studies report nucleolar dysfunction in Alzheimer{\textquoteright}s disease (AD). Studies have reported a decrease in both total nucleolar volume and transcriptional activity of the nucleolar organizing regions. Ribosomes appear to be targeted by oxidation and reduced protein translation has been reported. In addition, several nucleolar proteins are dysregulated and some of these appear to be implicated in classical AD pathology. Some studies also suggest that the nucleolar stress response may be activated in AD, albeit this latter research is rather limited and requires further investigation. The purpose of this review is to draw the connections of all these studies together and signify that there are clear changes in the nucleolus and the ribosomes in AD. The nucleolus is therefore an organelle that requires more attention than previously given in relation to understanding the biological mechanisms underlying the disease.",
author = "Caitlin Nyhus and Maria Pihl and Poul Hyttel and Hall, {Vanessa Jane}",
year = "2019",
doi = "10.1515/revneuro-2018-0104",
language = "English",
volume = "30",
pages = "685–700",
journal = "Reviews in the Neurosciences",
issn = "0334-1763",
publisher = "Walterde Gruyter GmbH",
number = "7",

}

RIS

TY - JOUR

T1 - Evidence for nucleolar dysfunction in Alzheimer's disease

AU - Nyhus, Caitlin

AU - Pihl, Maria

AU - Hyttel, Poul

AU - Hall, Vanessa Jane

PY - 2019

Y1 - 2019

N2 - The nucleolus is a dynamically changing organelle that is central to a number of important cellular functions. Not only is it important for ribosome biogenesis, but it also reacts to stress by instigating a nucleolar stress response and is further involved in regulating the cell cycle. Several studies report nucleolar dysfunction in Alzheimer’s disease (AD). Studies have reported a decrease in both total nucleolar volume and transcriptional activity of the nucleolar organizing regions. Ribosomes appear to be targeted by oxidation and reduced protein translation has been reported. In addition, several nucleolar proteins are dysregulated and some of these appear to be implicated in classical AD pathology. Some studies also suggest that the nucleolar stress response may be activated in AD, albeit this latter research is rather limited and requires further investigation. The purpose of this review is to draw the connections of all these studies together and signify that there are clear changes in the nucleolus and the ribosomes in AD. The nucleolus is therefore an organelle that requires more attention than previously given in relation to understanding the biological mechanisms underlying the disease.

AB - The nucleolus is a dynamically changing organelle that is central to a number of important cellular functions. Not only is it important for ribosome biogenesis, but it also reacts to stress by instigating a nucleolar stress response and is further involved in regulating the cell cycle. Several studies report nucleolar dysfunction in Alzheimer’s disease (AD). Studies have reported a decrease in both total nucleolar volume and transcriptional activity of the nucleolar organizing regions. Ribosomes appear to be targeted by oxidation and reduced protein translation has been reported. In addition, several nucleolar proteins are dysregulated and some of these appear to be implicated in classical AD pathology. Some studies also suggest that the nucleolar stress response may be activated in AD, albeit this latter research is rather limited and requires further investigation. The purpose of this review is to draw the connections of all these studies together and signify that there are clear changes in the nucleolus and the ribosomes in AD. The nucleolus is therefore an organelle that requires more attention than previously given in relation to understanding the biological mechanisms underlying the disease.

U2 - 10.1515/revneuro-2018-0104

DO - 10.1515/revneuro-2018-0104

M3 - Review

C2 - 30849050

VL - 30

SP - 685

EP - 700

JO - Reviews in the Neurosciences

JF - Reviews in the Neurosciences

SN - 0334-1763

IS - 7

ER -

ID: 212680284