Fluorescent light energy in wound healing: When is a photon something more?
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Accepted author manuscript, 511 KB, PDF document
Fluorescent Light Energy (FLE) is a unique form of photobiomodulation that stimulates healing, reduces inflammation, and alleviates pain. The system works by exciting a chromophore in a topical substrate, which emits FLE with a broad spectral range (∼400-700 nm) that is delivered to the target tissue below. Results from in vivo and in vitro studies have shown FLE modulates inflammation via down-regulation of pro-inflammatory cytokines such as IL-6 and TNF-α and stimulates mitochondria biogenesis1. A recent study showed FLE-stimulated cells responded more potently compared to cells treated with light from an LED light source ("Mimicking Lamp") designed to generate the same emission spectra and power intensity profile as FLE2. FLE-treated human dermal fibroblasts (HDF) experienced up-regulated collagen production, while a minor and nonsignificant effect was observed for the Mimicking Lamp-treated HDFs. These results suggest that photons generated by FLE either penetrate tissue differently or are absorbed differently compared to photons from a LED light source. Photonic properties of FLE that could impact tissue penetration or absorption may include polarity or coherency, leading to different cellular responses. To investigate if light polarity may influence cellular responses to FLE stimulation, the present study applied linear and circular-polarizing filters to investigate the influence of FLE's polarity on immune parameters. The data suggest that FLE polarity contributes to its impact on biological systems. Furthermore, the immunemodulatory impact of FLE was investgated in a pilot study on a human ex vivo skin model suggesting that central myeloid immune surface markes are modulated by FLE.
Original language | English |
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Title of host publication | Mechanisms of Photobiomodulation Therapy XV |
Editors | Michael R. Hamblin, James D. Carroll, Praveen Arany |
Number of pages | 9 |
Publisher | SPIE - International Society for Optical Engineering |
Publication date | 2020 |
Article number | 112210A |
ISBN (Electronic) | 9781510632059 |
DOIs | |
Publication status | Published - 2020 |
Event | Mechanisms of Photobiomodulation Therapy XV 2020 - San Francisco, United States Duration: 1 Feb 2020 → … |
Conference
Conference | Mechanisms of Photobiomodulation Therapy XV 2020 |
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Land | United States |
By | San Francisco |
Periode | 01/02/2020 → … |
Sponsor | The Society of Photo-Optical Instrumentation Engineers (SPIE) |
Series | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
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Volume | 11221 |
ISSN | 1605-7422 |
- Cellular Response, Fluorescence Biomodulation, Fluorescent Light Energy, Light Polarity, Wound Healing
Research areas
ID: 271545400