Metabolic Syndrome and Related Factors in Chinese Children and Adolescents: Analysis from a Chinese National Study
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Metabolic Syndrome and Related Factors in Chinese Children and Adolescents : Analysis from a Chinese National Study. / Zhu, Yanna; Zheng, Hao; Zou, Zhiyong; Jing, Jin; Ma, Yinghua; Wang, Haijun; Luo, Jiayou; Zhang, Xin; Luo, Chunyan; Wang, Hong; Zhao, Haiping; Pan, Dehong; Sangild, Per; Karmacharya, Biraj M; Ma, Jun; Chen, Yajun.
In: Journal of Atherosclerosis and Thrombosis, Vol. 27, No. 6, 2020, p. 534-544.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Metabolic Syndrome and Related Factors in Chinese Children and Adolescents
T2 - Analysis from a Chinese National Study
AU - Zhu, Yanna
AU - Zheng, Hao
AU - Zou, Zhiyong
AU - Jing, Jin
AU - Ma, Yinghua
AU - Wang, Haijun
AU - Luo, Jiayou
AU - Zhang, Xin
AU - Luo, Chunyan
AU - Wang, Hong
AU - Zhao, Haiping
AU - Pan, Dehong
AU - Sangild, Per
AU - Karmacharya, Biraj M
AU - Ma, Jun
AU - Chen, Yajun
PY - 2020
Y1 - 2020
N2 - AIMS: Metabolic syndrome (MetS) has become a worldwide epidemic; however, few studies have described its status in Chinese children. This study aimed to estimate MetS status and its associations with geography, economic development, birth weight, and parental education of Chinese children and adolescents.METHODS: Data were derived from 15,045 participants aged 7-18 years across seven Chinese provinces. Physical measurement and blood tests were conducted to assess the five classical MetS components described by the International Diabetes Federation, including abdominal obesity (the essential component), high blood pressure, low high-density cholesterol (HDL-C), high triglyceride, and elevated fasting glucose (FG). Logistic regression was adopted to explore possible associations between MetS and other factors.RESULTS: Overall, MetS prevalence was 2.3%, higher in males (2.8% vs. 1.7% in females), northern regions (3.1%), more developed regions (2.9%), and older participants (aged 16-18 years) (P<0.05 for all). Among the five MetS components, abdominal obesity and low HDL-C level were most prevalent (21.8% and 14.4%), and 35.9% of the participants had at least one component. In logistic regression, MetS itself did not correlate with birth weight or parental education. High birth weight was positively correlated with abdominal obesity (odds ratio, 1.48) butnegatively associated with elevated FG (odds ratio, 0.49). Concusions: MetS itself was not common in Chinese children and adolescents, whereas its certain components were far more prevalent. Children from North China, more-developed areas, and at an older age were more likely to develop MetS. Strategies designed to prevent pediatric MetS in China should focus on prevalent components as well as its geographic and economic development predilections.
AB - AIMS: Metabolic syndrome (MetS) has become a worldwide epidemic; however, few studies have described its status in Chinese children. This study aimed to estimate MetS status and its associations with geography, economic development, birth weight, and parental education of Chinese children and adolescents.METHODS: Data were derived from 15,045 participants aged 7-18 years across seven Chinese provinces. Physical measurement and blood tests were conducted to assess the five classical MetS components described by the International Diabetes Federation, including abdominal obesity (the essential component), high blood pressure, low high-density cholesterol (HDL-C), high triglyceride, and elevated fasting glucose (FG). Logistic regression was adopted to explore possible associations between MetS and other factors.RESULTS: Overall, MetS prevalence was 2.3%, higher in males (2.8% vs. 1.7% in females), northern regions (3.1%), more developed regions (2.9%), and older participants (aged 16-18 years) (P<0.05 for all). Among the five MetS components, abdominal obesity and low HDL-C level were most prevalent (21.8% and 14.4%), and 35.9% of the participants had at least one component. In logistic regression, MetS itself did not correlate with birth weight or parental education. High birth weight was positively correlated with abdominal obesity (odds ratio, 1.48) butnegatively associated with elevated FG (odds ratio, 0.49). Concusions: MetS itself was not common in Chinese children and adolescents, whereas its certain components were far more prevalent. Children from North China, more-developed areas, and at an older age were more likely to develop MetS. Strategies designed to prevent pediatric MetS in China should focus on prevalent components as well as its geographic and economic development predilections.
U2 - 10.5551/jat.50591
DO - 10.5551/jat.50591
M3 - Journal article
C2 - 31827007
VL - 27
SP - 534
EP - 544
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 6
ER -
ID: 238753731