Pathological Diagnosis of Pulmonary Aspergillosis
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Pathological Diagnosis of Pulmonary Aspergillosis. / Jensen, Henrik E.; Becker, Cecilie B.
In: Seminars in Respiratory and Critical Care Medicine, Vol. 45, No. 1, 2024, p. 41-49.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Pathological Diagnosis of Pulmonary Aspergillosis
AU - Jensen, Henrik E.
AU - Becker, Cecilie B.
N1 - Publisher Copyright: © 2024. Thieme. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Pulmonary aspergillosis constitutes an increasingly prevalent and potentially fatal complex of mycotic diseases, caused by different species of Aspergillus. The broad spectrum of pathological manifestations associated with pulmonary aspergillosis necessitates a differentiation of commensalism from saprophytic colonization, hypersensitivity reactions, and true invasive infections, which highlights the importance of histopathology as a gold standard in a diagnostic setting. For the past decades, changes in terminology and contradicting contributions from different diagnostic disciplines have made the classification of pulmonary aspergillosis rather confusing. This review offers a categorization of aspergillosis lesions based on what can be histopathologically identified and distinguished, differentiating between acute invasive infection and forms of subacute, chronic, and allergic diseases and coinfections, and summarizes important manifestations of lesions associated with the different forms of pulmonary aspergillosis.
AB - Pulmonary aspergillosis constitutes an increasingly prevalent and potentially fatal complex of mycotic diseases, caused by different species of Aspergillus. The broad spectrum of pathological manifestations associated with pulmonary aspergillosis necessitates a differentiation of commensalism from saprophytic colonization, hypersensitivity reactions, and true invasive infections, which highlights the importance of histopathology as a gold standard in a diagnostic setting. For the past decades, changes in terminology and contradicting contributions from different diagnostic disciplines have made the classification of pulmonary aspergillosis rather confusing. This review offers a categorization of aspergillosis lesions based on what can be histopathologically identified and distinguished, differentiating between acute invasive infection and forms of subacute, chronic, and allergic diseases and coinfections, and summarizes important manifestations of lesions associated with the different forms of pulmonary aspergillosis.
KW - Aspergillus spp.
KW - fungal histology
KW - histopathology
KW - pulmonary aspergillosis
U2 - 10.1055/s-0043-1776757
DO - 10.1055/s-0043-1776757
M3 - Review
C2 - 38266999
AN - SCOPUS:85183476854
VL - 45
SP - 41
EP - 49
JO - Seminars in Respiratory and Critical Care Medicine
JF - Seminars in Respiratory and Critical Care Medicine
SN - 1069-3424
IS - 1
ER -
ID: 384254691