Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy: Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity
Research output: Contribution to journal › Journal article › Research › peer-review
Enzyme activities have been measured in needle biopsies from kidneys of pigs fed 1 ppm or 0.2 ppm of ochratoxin A for 1-5 wks. After feeding 1 ppm toxin for 1 wk, the activity of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) was decreased by 40% and remained inhibited until the termination of the experiment (5 wk). The activity of gamma-glutamyl transpeptidase, a brush-border enzyme found in the proximal tubules, was reduced to a similar degree and remained inhibited. The activities of hexokinase, a cytosolic enzyme of general distribution in the nephron, and phosphate-dependent.
Original language | English |
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Journal | Journal of Toxicology and Environmental Health |
Volume | 23 |
Issue number | 1 |
Pages (from-to) | 1-14 |
Number of pages | 14 |
ISSN | 0098-4108 |
DOIs | |
Publication status | Published - Jan 1988 |
ID: 285717697