Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

Research output: Contribution to journal › Journal article › Research › peer-review

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Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. / Fisker, Line; Krych, Lukasz; Engkilde, Kåre; Nielsen, Dennis Sandris; Kot, Witold Piotr; Hansen, Camilla Hartmann Friis; Hansen, Axel Kornerup.

In: Scientific Reports, Vol. 7, 44385, 2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fisker, L, Krych, L, Engkilde, K, Nielsen, DS, Kot, WP, Hansen, CHF & Hansen, AK 2017, 'Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice', Scientific Reports, vol. 7, 44385. https://doi.org/10.1038/srep44385

APA

Fisker, L., Krych, L., Engkilde, K., Nielsen, D. S., Kot, W. P., Hansen, C. H. F., & Hansen, A. K. (2017). Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. Scientific Reports, 7, [44385]. https://doi.org/10.1038/srep44385

Vancouver

Fisker L, Krych L, Engkilde K, Nielsen DS, Kot WP, Hansen CHF et al. Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. Scientific Reports. 2017;7. 44385. https://doi.org/10.1038/srep44385

Author

Fisker, Line ; Krych, Lukasz ; Engkilde, Kåre ; Nielsen, Dennis Sandris ; Kot, Witold Piotr ; Hansen, Camilla Hartmann Friis ; Hansen, Axel Kornerup. / Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. In: Scientific Reports. 2017 ; Vol. 7.

Bibtex

@article{27218a4b18c547dab9a6f7a5b3b67ddb,
title = "Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice",
abstract = "Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.",
author = "Line Fisker and Lukasz Krych and K{\aa}re Engkilde and Nielsen, {Dennis Sandris} and Kot, {Witold Piotr} and Hansen, {Camilla Hartmann Friis} and Hansen, {Axel Kornerup}",
year = "2017",
doi = "10.1038/srep44385",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

AU - Fisker, Line

AU - Krych, Lukasz

AU - Engkilde, Kåre

AU - Nielsen, Dennis Sandris

AU - Kot, Witold Piotr

AU - Hansen, Camilla Hartmann Friis

AU - Hansen, Axel Kornerup

PY - 2017

Y1 - 2017

N2 - Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.

AB - Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.

U2 - 10.1038/srep44385

DO - 10.1038/srep44385

M3 - Journal article

C2 - 28290517

AN - SCOPUS:85015307682

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 44385

ER -

ID: 176656151