Synthesis, discovery, and quantitation of dihomo-Isofurans: Biomarkers for in vivo adrenic acid peroxidation
Research output: Contribution to journal › Journal article › Research › peer-review
The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.
Original language | English |
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Journal | Angewandte Chemie International Edition |
Volume | 53 |
Issue number | 24 |
Pages (from-to) | 6249-6252 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 2014 |
ID: 113247957