The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen

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The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen. / Deschain, T.; Fabricius, J.; Berendt, M.; Fredholm, M.; Karlskov-Mortensen, P.

In: Animal Genetics, Vol. 52, No. 5, 2021, p. 762-766.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Deschain, T, Fabricius, J, Berendt, M, Fredholm, M & Karlskov-Mortensen, P 2021, 'The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen', Animal Genetics, vol. 52, no. 5, pp. 762-766. https://doi.org/10.1111/age.13128

APA

Deschain, T., Fabricius, J., Berendt, M., Fredholm, M., & Karlskov-Mortensen, P. (2021). The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen. Animal Genetics, 52(5), 762-766. https://doi.org/10.1111/age.13128

Vancouver

Deschain T, Fabricius J, Berendt M, Fredholm M, Karlskov-Mortensen P. The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen. Animal Genetics. 2021;52(5):762-766. https://doi.org/10.1111/age.13128

Author

Deschain, T. ; Fabricius, J. ; Berendt, M. ; Fredholm, M. ; Karlskov-Mortensen, P. / The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen. In: Animal Genetics. 2021 ; Vol. 52, No. 5. pp. 762-766.

Bibtex

@article{ccefadc981214a5eab98bfb752166e3e,
title = "The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen",
abstract = "The dog breed Petit Basset Griffon Vendeen has a relatively high prevalence of idiopathic epilepsy compared to other dog breeds and previous studies have suggested a genetic cause of the disease in this breed. Based on these observations, a genome-wide association study was performed to identify possible epilepsy-causing loci. The study included 30 unaffected and 23 affected dogs, genotyping of 170K SNPs, and data analysis using plink and emmax. Suggestive associations at CFA13, CFA24 and CFA35 were identified with markers close to three strong candidate genes. However, subsequent sequencing of exons of the three genes did not reveal sequence variations, which could explain development of the disease. This is, to our knowledge, the first report on loci and genes with a possible connection to idiopathic epilepsy in Petit Basset Griffon Vendeen. However, further studies are needed to conclusively identify the genetic cause of idiopathic epilepsy in this dog breed.",
keywords = "dog, epilepsy, genome-wide association study, Petit Basset Griffon Vendeen",
author = "T. Deschain and J. Fabricius and M. Berendt and M. Fredholm and P. Karlskov-Mortensen",
note = "Publisher Copyright: {\textcopyright} 2021 Stichting International Foundation for Animal Genetics",
year = "2021",
doi = "10.1111/age.13128",
language = "English",
volume = "52",
pages = "762--766",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - The first genome-wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen

AU - Deschain, T.

AU - Fabricius, J.

AU - Berendt, M.

AU - Fredholm, M.

AU - Karlskov-Mortensen, P.

N1 - Publisher Copyright: © 2021 Stichting International Foundation for Animal Genetics

PY - 2021

Y1 - 2021

N2 - The dog breed Petit Basset Griffon Vendeen has a relatively high prevalence of idiopathic epilepsy compared to other dog breeds and previous studies have suggested a genetic cause of the disease in this breed. Based on these observations, a genome-wide association study was performed to identify possible epilepsy-causing loci. The study included 30 unaffected and 23 affected dogs, genotyping of 170K SNPs, and data analysis using plink and emmax. Suggestive associations at CFA13, CFA24 and CFA35 were identified with markers close to three strong candidate genes. However, subsequent sequencing of exons of the three genes did not reveal sequence variations, which could explain development of the disease. This is, to our knowledge, the first report on loci and genes with a possible connection to idiopathic epilepsy in Petit Basset Griffon Vendeen. However, further studies are needed to conclusively identify the genetic cause of idiopathic epilepsy in this dog breed.

AB - The dog breed Petit Basset Griffon Vendeen has a relatively high prevalence of idiopathic epilepsy compared to other dog breeds and previous studies have suggested a genetic cause of the disease in this breed. Based on these observations, a genome-wide association study was performed to identify possible epilepsy-causing loci. The study included 30 unaffected and 23 affected dogs, genotyping of 170K SNPs, and data analysis using plink and emmax. Suggestive associations at CFA13, CFA24 and CFA35 were identified with markers close to three strong candidate genes. However, subsequent sequencing of exons of the three genes did not reveal sequence variations, which could explain development of the disease. This is, to our knowledge, the first report on loci and genes with a possible connection to idiopathic epilepsy in Petit Basset Griffon Vendeen. However, further studies are needed to conclusively identify the genetic cause of idiopathic epilepsy in this dog breed.

KW - dog

KW - epilepsy

KW - genome-wide association study

KW - Petit Basset Griffon Vendeen

U2 - 10.1111/age.13128

DO - 10.1111/age.13128

M3 - Journal article

C2 - 34383319

AN - SCOPUS:85112342400

VL - 52

SP - 762

EP - 766

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 5

ER -

ID: 276902427