The microbiome and rodent models of immune mediated diseases

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The microbiome and rodent models of immune mediated diseases. / Hansen, Axel Kornerup; Hansen, Camilla Hartmann Friis.

In: Mammalian Genome, Vol. 32, 2021, p. 251–262.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hansen, AK & Hansen, CHF 2021, 'The microbiome and rodent models of immune mediated diseases', Mammalian Genome, vol. 32, pp. 251–262. https://doi.org/10.1007/s00335-021-09866-4

APA

Hansen, A. K., & Hansen, C. H. F. (2021). The microbiome and rodent models of immune mediated diseases. Mammalian Genome, 32, 251–262. https://doi.org/10.1007/s00335-021-09866-4

Vancouver

Hansen AK, Hansen CHF. The microbiome and rodent models of immune mediated diseases. Mammalian Genome. 2021;32:251–262. https://doi.org/10.1007/s00335-021-09866-4

Author

Hansen, Axel Kornerup ; Hansen, Camilla Hartmann Friis. / The microbiome and rodent models of immune mediated diseases. In: Mammalian Genome. 2021 ; Vol. 32. pp. 251–262.

Bibtex

@article{628ff02dd0ec417a8fde1e072664926a,
title = "The microbiome and rodent models of immune mediated diseases",
abstract = "Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota. Until 10 years ago the impact of the microbiota on the outcome of rodent studies was ignored, but today it is clear that the phenotype of rodent models differs essentially in relation to the environment of origin, i.e. different breeders or different rooms. In this review, we outline the mechanisms behind gut bacterial impact on rodent models of immune mediated diseases, and how differences in environment of origin leads to phenotypic model differences within research areas such as infectious diseases and vaccine development, the metabolic syndrome, gut immunity and inflammation, autoimmunity and allergy. Finally, we sum up some tools to handle this impact to increase reproducibility and translatability of rodent models.",
author = "Hansen, {Axel Kornerup} and Hansen, {Camilla Hartmann Friis}",
year = "2021",
doi = "10.1007/s00335-021-09866-4",
language = "English",
volume = "32",
pages = "251–262",
journal = "Mammalian Genome",
issn = "0938-8990",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - The microbiome and rodent models of immune mediated diseases

AU - Hansen, Axel Kornerup

AU - Hansen, Camilla Hartmann Friis

PY - 2021

Y1 - 2021

N2 - Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota. Until 10 years ago the impact of the microbiota on the outcome of rodent studies was ignored, but today it is clear that the phenotype of rodent models differs essentially in relation to the environment of origin, i.e. different breeders or different rooms. In this review, we outline the mechanisms behind gut bacterial impact on rodent models of immune mediated diseases, and how differences in environment of origin leads to phenotypic model differences within research areas such as infectious diseases and vaccine development, the metabolic syndrome, gut immunity and inflammation, autoimmunity and allergy. Finally, we sum up some tools to handle this impact to increase reproducibility and translatability of rodent models.

AB - Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota. Until 10 years ago the impact of the microbiota on the outcome of rodent studies was ignored, but today it is clear that the phenotype of rodent models differs essentially in relation to the environment of origin, i.e. different breeders or different rooms. In this review, we outline the mechanisms behind gut bacterial impact on rodent models of immune mediated diseases, and how differences in environment of origin leads to phenotypic model differences within research areas such as infectious diseases and vaccine development, the metabolic syndrome, gut immunity and inflammation, autoimmunity and allergy. Finally, we sum up some tools to handle this impact to increase reproducibility and translatability of rodent models.

U2 - 10.1007/s00335-021-09866-4

DO - 10.1007/s00335-021-09866-4

M3 - Review

C2 - 33792799

AN - SCOPUS:85103386370

VL - 32

SP - 251

EP - 262

JO - Mammalian Genome

JF - Mammalian Genome

SN - 0938-8990

ER -

ID: 259880793