The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
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The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure. / Bahl, Martin Iain; Honoré, Anabelle Legarth; Skønager, Sanne Tygesen; Honoré, Oliver Legarth; Clausen, Tove; Andresen, Lars; Hammer, Anne Sofie.
In: Scientific Reports, Vol. 10, No. 1, 20434, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
AU - Bahl, Martin Iain
AU - Honoré, Anabelle Legarth
AU - Skønager, Sanne Tygesen
AU - Honoré, Oliver Legarth
AU - Clausen, Tove
AU - Andresen, Lars
AU - Hammer, Anne Sofie
PY - 2020
Y1 - 2020
N2 - On many mink farms, antibiotics are used extensively during the lactation period to reduce the prevalence and severity of pre-weaning diarrhoea (PWD) in mink kits (also referred to as greasy kit syndrome). Concerns have been raised, that routine treatment of PWD with antibiotics could affect the natural successional development of the gut microbiota, which may have long lasting consequences. Here we investigated the effects of early life antibiotic treatment administered for 1 week (postnatal days 13–20). Two routes of antibiotic administration were compared to a non-treated control group (CTR, n = 24). Routes of administration included indirect treatment, through the milk from dams receiving antibiotics by intramuscular administration (ABX_D, n = 24) and direct treatment by intramuscular administration to the kits (ABX_K, n = 24). A tendency for slightly increased weight at termination (Day 205) was observed in the ABX_K group. The gut microbiota composition was profiled by 16S rRNA gene sequencing at eight time points between Day 7 and Day 205. A clear successional development of the gut microbiota composition was observed and both treatment regimens caused detectable changes in the gut microbiota until at least eight days after treatment ceased. At termination, a significant positive correlation was identified between microbial diversity and animal weight.
AB - On many mink farms, antibiotics are used extensively during the lactation period to reduce the prevalence and severity of pre-weaning diarrhoea (PWD) in mink kits (also referred to as greasy kit syndrome). Concerns have been raised, that routine treatment of PWD with antibiotics could affect the natural successional development of the gut microbiota, which may have long lasting consequences. Here we investigated the effects of early life antibiotic treatment administered for 1 week (postnatal days 13–20). Two routes of antibiotic administration were compared to a non-treated control group (CTR, n = 24). Routes of administration included indirect treatment, through the milk from dams receiving antibiotics by intramuscular administration (ABX_D, n = 24) and direct treatment by intramuscular administration to the kits (ABX_K, n = 24). A tendency for slightly increased weight at termination (Day 205) was observed in the ABX_K group. The gut microbiota composition was profiled by 16S rRNA gene sequencing at eight time points between Day 7 and Day 205. A clear successional development of the gut microbiota composition was observed and both treatment regimens caused detectable changes in the gut microbiota until at least eight days after treatment ceased. At termination, a significant positive correlation was identified between microbial diversity and animal weight.
U2 - 10.1038/s41598-020-77417-z
DO - 10.1038/s41598-020-77417-z
M3 - Journal article
C2 - 33235332
AN - SCOPUS:85096570117
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 20434
ER -
ID: 252681573