The role of immunonutrients in the prevention of necrotizing enterocolitis in preterm very low birth weight infants
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The role of immunonutrients in the prevention of necrotizing enterocolitis in preterm very low birth weight infants. / Zhou, Ping; Li, Yanqi; Ma, Li-Ya; Lin, Hung-Chih.
In: Nutrients, Vol. 7, No. 9, 09.2015, p. 7256-70.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The role of immunonutrients in the prevention of necrotizing enterocolitis in preterm very low birth weight infants
AU - Zhou, Ping
AU - Li, Yanqi
AU - Ma, Li-Ya
AU - Lin, Hung-Chih
PY - 2015/9
Y1 - 2015/9
N2 - Necrotizing enterocolitis (NEC) is a critical intestinal emergency condition, which mainly occurs in preterm very low birth weight (PVLBW) infants. Despite remarkable advances in the care of PVLBW infants, with considerable improvement of the survival rate in recent decades, the incidence of NEC and NEC-related mortality have not declined accordingly. The fast progression from nonspecific signs to extensive necrosis also makes primary prevention the first priority. Recently, increasing evidence has indicated the important role of several nutrients in primary prevention of NEC. Therefore, the aim of this review is to summarize some potential immunomodulatory nutrients in the prevention of NEC, including bovine colostrum, probiotics, prebiotics (e.g., human milk oligosaccharides), long chain polyunsaturated fatty acids, and amino acids (glutamine, cysteine and N-acetylcysteine, l-arginine and l-citrulline). Based on current research evidence, probiotics are the most documented effective method to prevent NEC, while others still require further investigation in animal studies and clinical randomized controlled trials.
AB - Necrotizing enterocolitis (NEC) is a critical intestinal emergency condition, which mainly occurs in preterm very low birth weight (PVLBW) infants. Despite remarkable advances in the care of PVLBW infants, with considerable improvement of the survival rate in recent decades, the incidence of NEC and NEC-related mortality have not declined accordingly. The fast progression from nonspecific signs to extensive necrosis also makes primary prevention the first priority. Recently, increasing evidence has indicated the important role of several nutrients in primary prevention of NEC. Therefore, the aim of this review is to summarize some potential immunomodulatory nutrients in the prevention of NEC, including bovine colostrum, probiotics, prebiotics (e.g., human milk oligosaccharides), long chain polyunsaturated fatty acids, and amino acids (glutamine, cysteine and N-acetylcysteine, l-arginine and l-citrulline). Based on current research evidence, probiotics are the most documented effective method to prevent NEC, while others still require further investigation in animal studies and clinical randomized controlled trials.
U2 - 10.3390/nu7095334
DO - 10.3390/nu7095334
M3 - Journal article
C2 - 26343718
VL - 7
SP - 7256
EP - 7270
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 9
ER -
ID: 160671479