Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Standard
Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development. / Petkov, Stoyan; Freude, Kristine; Mashayekhi-Nezamabadi, Kaveh; Hyttel, Poul; Hall, Vanessa.
Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction. ed. / Heide Schatten; Gheorghe M. Constantinescu. Wiley-Blackwell, 2017. p. 485-508.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - CHAP
T1 - Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development
AU - Petkov, Stoyan
AU - Freude, Kristine
AU - Mashayekhi-Nezamabadi, Kaveh
AU - Hyttel, Poul
AU - Hall, Vanessa
PY - 2017/3
Y1 - 2017/3
N2 - The lack in production of bona fide porcine pluripotent stem cells has definitely been hampered by a lack of research into porcine embryo development. Embryonic development in mammals is the extraordinary transition of a single-celled fertilized zygote into a complex fetus, which occurs in the uterus of the maternal adult during the early stages of gestation. Biomedical pig models could serve as genetic backgrounds for establishment of embryonic stem cells (ESCs) or other pluripotent stem cells (such as iPSC), which may be used to model and study diseases in vitro. This chapter provides insight into the current knowledge of pluripotent states in the developing pig embryo and the current status in establishment of bona fide porcine ESC (pESC) and piPSCs. It reflects the potential causes underlying the difficulty in establishing pluripotent stem cells and reviews recent data on global profiling of the pluripotent states in this species.
AB - The lack in production of bona fide porcine pluripotent stem cells has definitely been hampered by a lack of research into porcine embryo development. Embryonic development in mammals is the extraordinary transition of a single-celled fertilized zygote into a complex fetus, which occurs in the uterus of the maternal adult during the early stages of gestation. Biomedical pig models could serve as genetic backgrounds for establishment of embryonic stem cells (ESCs) or other pluripotent stem cells (such as iPSC), which may be used to model and study diseases in vitro. This chapter provides insight into the current knowledge of pluripotent states in the developing pig embryo and the current status in establishment of bona fide porcine ESC (pESC) and piPSCs. It reflects the potential causes underlying the difficulty in establishing pluripotent stem cells and reviews recent data on global profiling of the pluripotent states in this species.
U2 - 10.1002/9781118881286.ch19
DO - 10.1002/9781118881286.ch19
M3 - Book chapter
SN - 9781118881606
SP - 485
EP - 508
BT - Animal Models and Human Reproduction
A2 - Schatten, Heide
A2 - Constantinescu, Gheorghe M.
PB - Wiley-Blackwell
ER -
ID: 173984991