Veterinary parasitology - the VETPAR group

Drug resistance in parasites and alternative control

Anthelmintic resistance is an increasing problem in modern livestock production and is a major driving force for alternative control. We are surveying populations for drug resistance and are currently exploring alternative control options, mainly nematode destroying fungi, dietary phytochemicals, bioactive forages for grazing, and pre-/probiotics. Also research on mechanisms of drug action and uptake in worms. 

Exploring host-parasite interactions

Both hosts and parasites are complex multicellular organisms that have co-evolved for millions of years. Molecular methods are used to identify parasites and explore transmission routes. We have shown how feed additives like inulin may affect the gut microbiota and helminth populations, as well as immune function.

Clinical parasitology in companion animals and livestock

Knowledge on prevailing parasites in different regions, their impact, and a basic understanding of epidemiology in different production systems (livestock) or environments (companion animals) are essential to prevention and treatment.

We focus currently on fasciolosis in cattle and wildlife, and strongyle infections in cattle, sheep, cats and dogs. In dogs, we have shown that false positive findings of parasite elements in faeces are very common and cause diagnostic problems.

Hansen et al. (2019). Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk. Journal of Extracellular Vesicles. 8(1) [1578116] https://doi.org/10.1080/20013078.2019.1578116
In this study we demonstrate that extracellular vesicles are released from larval and adult stages Ascaris suum and they carry a cargo of miRNA and protein that play a role in host–parasite interactions, e.g. immuno-modulation.

Thapa et al. (2018). Effect of the nematophagous fungus Pochonia chlamydosporia on soil content of ascarid eggs and infection levels in exposed hens. Parasites & Vectors, 11(1), 319-
https://doi.org/10.1186/s13071-018-2898-1
Here we have shown that the hard-shelled eggs of ascarids can be “cracked” by this biological agent but the natural soil flora outcompetes the nematode-eating fungi.

Takeuchi-Storm et al. (2018). Patterns of Fasciola hepatica infection in Danish dairy cattle: implications for on-farm control of the parasite based on different diagnostic methods. Parasites & Vectors, 11, s. 1-18 674. https://doi.org/10.1186/s13071-017-2504-y
 We established the temporal pattern of fasciolosis and investigated the relationship of diagnostic parameters: egg counts, antibodies and faecal antigen testing on two organic and two conventional dairy farms.

PARAGUT 

PARASITES AND PLANTS