Basic host-parasite interactions

Both hosts and parasites are complex multicellular organisms that have co-evolved for millions of years. Their interactions are therefore rather sophisticated and they respond to each other in intricate ways, depending on factors such as the host and parasite species, gut environment (microbiome) and diet, host factors like age and gender, and co-infections with other pathogens.

We investigate the nature of host immune responses to better understand host resistance and parasite-induced immuno-modulation. We also explore changes in the gut microbiome in relation to parasites, and how these interact with other factors such as diet.

In this way certain nematode infections, e.g. roundworms, also affect the immunity to other pathogens and autoimmune disorders. The effect of different kinds of feed additives/plant compounds on the immune response and parasites is also investigated by means of experimental infections, gene expression analysis, immunoassays and functional in vitro analysis of dendritic cells and T-cells.