Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 3: Amprolium
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 3: Amprolium. / EFSA Panel on Biological Hazards (BIOHAZ); Koutsoumanis, Konstantinos; Allende, Ana; Alvarez-Ordóñez, Avelino; Bolton, Declan; Bover-Cid, Sara; Chemaly, Marianne; Davies, Robert; De Cesare, Alessandra; Herman, Lieve; Hilbert, Friederike; Lindqvist, Roland; Nauta, Maarten; Ru, Giuseppe; Simmons, Marion; Skandamis, Panagiotis; Suffredini, Elisabetta; Andersson, Dan I; Bampidis, Vasileios; Bengtsson-Palme, Johan; Bouchard, Damien; Ferran, Aude; Kouba, Maryline; López Puente, Secundino; López-Alonso, Marta; Nielsen, Søren Saxmose; Pechová, Alena; Petkova, Mariana; Girault, Sebastien; Broglia, Alessandro; Guerra, Beatriz; Innocenti, Matteo Lorenzo; Liébana, Ernesto; López-Gálvez, Gloria; Manini, Paola; Stella, Pietro; Peixe, Luisa.
In: EFSA Journal, Vol. 19, No. 10, e06854, 2021, p. 1-20.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 3: Amprolium
AU - EFSA Panel on Biological Hazards (BIOHAZ), null
AU - Koutsoumanis, Konstantinos
AU - Allende, Ana
AU - Alvarez-Ordóñez, Avelino
AU - Bolton, Declan
AU - Bover-Cid, Sara
AU - Chemaly, Marianne
AU - Davies, Robert
AU - De Cesare, Alessandra
AU - Herman, Lieve
AU - Hilbert, Friederike
AU - Lindqvist, Roland
AU - Nauta, Maarten
AU - Ru, Giuseppe
AU - Simmons, Marion
AU - Skandamis, Panagiotis
AU - Suffredini, Elisabetta
AU - Andersson, Dan I
AU - Bampidis, Vasileios
AU - Bengtsson-Palme, Johan
AU - Bouchard, Damien
AU - Ferran, Aude
AU - Kouba, Maryline
AU - López Puente, Secundino
AU - López-Alonso, Marta
AU - Nielsen, Søren Saxmose
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Girault, Sebastien
AU - Broglia, Alessandro
AU - Guerra, Beatriz
AU - Innocenti, Matteo Lorenzo
AU - Liébana, Ernesto
AU - López-Gálvez, Gloria
AU - Manini, Paola
AU - Stella, Pietro
AU - Peixe, Luisa
PY - 2021
Y1 - 2021
N2 - Abstract The specific concentrations of amprolium in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC for amprolium, it was not possible to conclude the assessment. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of amprolium in feed that showed to have an effect on growth promotion/increased yield were reported. The lack of antibacterial activity at clinically relevant concentrations for amprolium suggests that further studies relating to bacterial resistance are not a priority.
AB - Abstract The specific concentrations of amprolium in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC for amprolium, it was not possible to conclude the assessment. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of amprolium in feed that showed to have an effect on growth promotion/increased yield were reported. The lack of antibacterial activity at clinically relevant concentrations for amprolium suggests that further studies relating to bacterial resistance are not a priority.
KW - amprolium
KW - antimicrobial resistance
KW - subinhibitory concentration
KW - Feed Antimicrobial Resistance Selection Concentration (FARSC)
KW - growth promotion
KW - yield increase
KW - food-producing animals
U2 - 10.2903/j.efsa.2021.6854
DO - 10.2903/j.efsa.2021.6854
M3 - Journal article
C2 - 34729083
VL - 19
SP - 1
EP - 20
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 10
M1 - e06854
ER -
ID: 282610649