Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses. / Ryt-Hansen, Pia; Krog, Jesper Schak; Breum, Solvej Østergaard; Hjulsager, Charlotte Kristiane; Pedersen, Anders Gorm; Trebbien, Ramona; Larsen, Lars Erik.
In: eLife, Vol. 10, e60940, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses
AU - Ryt-Hansen, Pia
AU - Krog, Jesper Schak
AU - Breum, Solvej Østergaard
AU - Hjulsager, Charlotte Kristiane
AU - Pedersen, Anders Gorm
AU - Trebbien, Ramona
AU - Larsen, Lars Erik
N1 - Publisher Copyright: © 2021, eLife Sciences Publications Ltd. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Since the influenza pandemic in 2009, there has been an increased focus on swine influenza A virus (swIAV) surveillance. This paper describes the results of the surveillance of swIAV in Danish swine from 2011 to 2018. In total, 3800 submissions were received with a steady increase in swIAV positive submissions, reaching 56% in 2018. Full genome sequences were obtained from 129 swIAV positive samples. Altogether, 17 different circulating genotypes were identified including six novel reassortants harboring human seasonal IAV gene segments. The phylogenetic analysis revealed substantial genetic drift and also evidence of positive selection occurring mainly in antigenic sites of the hemagglutinin protein and confirmed the presence of a swine divergent cluster among the H lpdm09Nx (clade 1 A.3.3.2) viruses. The results provide essential data for the control of swIAV in pigs and emphasize the importance of contemporary surveillance for discovering novel swIAV strains posing a potential threat to the human population.
AB - Since the influenza pandemic in 2009, there has been an increased focus on swine influenza A virus (swIAV) surveillance. This paper describes the results of the surveillance of swIAV in Danish swine from 2011 to 2018. In total, 3800 submissions were received with a steady increase in swIAV positive submissions, reaching 56% in 2018. Full genome sequences were obtained from 129 swIAV positive samples. Altogether, 17 different circulating genotypes were identified including six novel reassortants harboring human seasonal IAV gene segments. The phylogenetic analysis revealed substantial genetic drift and also evidence of positive selection occurring mainly in antigenic sites of the hemagglutinin protein and confirmed the presence of a swine divergent cluster among the H lpdm09Nx (clade 1 A.3.3.2) viruses. The results provide essential data for the control of swIAV in pigs and emphasize the importance of contemporary surveillance for discovering novel swIAV strains posing a potential threat to the human population.
U2 - 10.7554/eLife.60940
DO - 10.7554/eLife.60940
M3 - Journal article
C2 - 34313225
AN - SCOPUS:85111842611
VL - 10
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e60940
ER -
ID: 280181229