Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs. / Kristensen, Charlotte; Jensen, Henrik E.; Trebbien, Ramona; Ryt-Hansen, Pia; Larsen, Lars E.

In: npj Viruses, Vol. 1, 8, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kristensen, C, Jensen, HE, Trebbien, R, Ryt-Hansen, P & Larsen, LE 2023, 'Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs', npj Viruses, vol. 1, 8. https://doi.org/10.1038/s44298-023-00009-x

APA

Kristensen, C., Jensen, H. E., Trebbien, R., Ryt-Hansen, P., & Larsen, L. E. (2023). Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs. npj Viruses, 1, [8]. https://doi.org/10.1038/s44298-023-00009-x

Vancouver

Kristensen C, Jensen HE, Trebbien R, Ryt-Hansen P, Larsen LE. Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs. npj Viruses. 2023;1. 8. https://doi.org/10.1038/s44298-023-00009-x

Author

Kristensen, Charlotte ; Jensen, Henrik E. ; Trebbien, Ramona ; Ryt-Hansen, Pia ; Larsen, Lars E. / Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs. In: npj Viruses. 2023 ; Vol. 1.

Bibtex

@article{e256088e793e42b99f3570f0ebef52b4,
title = "Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs",
abstract = "Influenza A virus (IAV) is an RNA virus that causes respiratory disease in a wide range of mammals including humans and pigs. Cav1.2 is a specific voltage-dependent calcium channel (VDCC) important for the internalization of IAV and VDCC inhibitors can decrease IAV disease severity in mice. In this paper, the distribution pattern of a range of VDCCs by immunohistochemistry and Cav1.2 by in situ hybridization in the porcine respiratory tract is documented for the first time. Furthermore, we showed co-localization of VDCC-positive and IAV-positive cells in experimentally infected pigs. These findings provide new perspectives on the IAV internalization process and pave the way for further research investigating the effect of VDDC inhibitors on the IAV infection dynamics in pigs, which could have relevance to humans too.",
author = "Charlotte Kristensen and Jensen, {Henrik E.} and Ramona Trebbien and Pia Ryt-Hansen and Larsen, {Lars E.}",
year = "2023",
doi = "10.1038/s44298-023-00009-x",
language = "English",
volume = "1",
journal = "npj Viruses",
issn = "2948-1767",
publisher = "Springer Nature",

}

RIS

TY - JOUR

T1 - Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs

AU - Kristensen, Charlotte

AU - Jensen, Henrik E.

AU - Trebbien, Ramona

AU - Ryt-Hansen, Pia

AU - Larsen, Lars E.

PY - 2023

Y1 - 2023

N2 - Influenza A virus (IAV) is an RNA virus that causes respiratory disease in a wide range of mammals including humans and pigs. Cav1.2 is a specific voltage-dependent calcium channel (VDCC) important for the internalization of IAV and VDCC inhibitors can decrease IAV disease severity in mice. In this paper, the distribution pattern of a range of VDCCs by immunohistochemistry and Cav1.2 by in situ hybridization in the porcine respiratory tract is documented for the first time. Furthermore, we showed co-localization of VDCC-positive and IAV-positive cells in experimentally infected pigs. These findings provide new perspectives on the IAV internalization process and pave the way for further research investigating the effect of VDDC inhibitors on the IAV infection dynamics in pigs, which could have relevance to humans too.

AB - Influenza A virus (IAV) is an RNA virus that causes respiratory disease in a wide range of mammals including humans and pigs. Cav1.2 is a specific voltage-dependent calcium channel (VDCC) important for the internalization of IAV and VDCC inhibitors can decrease IAV disease severity in mice. In this paper, the distribution pattern of a range of VDCCs by immunohistochemistry and Cav1.2 by in situ hybridization in the porcine respiratory tract is documented for the first time. Furthermore, we showed co-localization of VDCC-positive and IAV-positive cells in experimentally infected pigs. These findings provide new perspectives on the IAV internalization process and pave the way for further research investigating the effect of VDDC inhibitors on the IAV infection dynamics in pigs, which could have relevance to humans too.

U2 - 10.1038/s44298-023-00009-x

DO - 10.1038/s44298-023-00009-x

M3 - Journal article

VL - 1

JO - npj Viruses

JF - npj Viruses

SN - 2948-1767

M1 - 8

ER -

ID: 381842434