Safety and efficacy of a feed additive consisting of l-valine produced by Escherichia coli CCTCC M2020321 for all animal species (Kempex Holland BV)
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Safety and efficacy of a feed additive consisting of l-valine produced by Escherichia coli CCTCC M2020321 for all animal species (Kempex Holland BV). / Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Fašmon Durjava, Mojca; Kouba, Maryline; López-Alonso, Marta; López Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Galobart, Jaume; Pettenati, Elisa; Tarrés-Call, Jordi; EFSA Panel on Additives, Products or Substances used in Animal Feed (FEEDAP).
In: EFSA Journal, Vol. 20, No. 2, e07163, 2022.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Safety and efficacy of a feed additive consisting of l-valine produced by Escherichia coli CCTCC M2020321 for all animal species (Kempex Holland BV)
AU - Bampidis, Vasileios
AU - Azimonti, Giovanna
AU - Bastos, Maria de Lourdes
AU - Christensen, Henrik
AU - Dusemund, Birgit
AU - Fašmon Durjava, Mojca
AU - Kouba, Maryline
AU - López-Alonso, Marta
AU - López Puente, Secundino
AU - Marcon, Francesca
AU - Mayo, Baltasar
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Ramos, Fernando
AU - Sanz, Yolanda
AU - Villa, Roberto Edoardo
AU - Woutersen, Ruud
AU - Galobart, Jaume
AU - Pettenati, Elisa
AU - Tarrés-Call, Jordi
AU - EFSA Panel on Additives, Products or Substances used in Animal Feed (FEEDAP)
N1 - Publisher Copyright: © 2022 Wiley-VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority.
PY - 2022
Y1 - 2022
N2 - Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-valine as a nutritional additive for all animal species. The production strain and its DNA were not detected in the final additive. Therefore, the final product does not give raise to any safety concern with regard to the genetic modification of the production strain. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that l-valine produced using Escherichia coli CCTCC M2020321 is safe when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species. The FEEDAP Panel has concerns on the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of l-valine produced using E. coli CCTCC M2020321 in animal nutrition is considered safe for the consumers and for the environment. The FEEDAP Panel cannot conclude on the potential of l-valine produced using E. coli CCTCC M2020321 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The endotoxin activity of the additive does not represent a hazard for users handling the additive when exposed by inhalation. The additive l-valine produced by fermentation using E. coli CCTCC M2020321 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
AB - Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-valine as a nutritional additive for all animal species. The production strain and its DNA were not detected in the final additive. Therefore, the final product does not give raise to any safety concern with regard to the genetic modification of the production strain. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that l-valine produced using Escherichia coli CCTCC M2020321 is safe when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species. The FEEDAP Panel has concerns on the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of l-valine produced using E. coli CCTCC M2020321 in animal nutrition is considered safe for the consumers and for the environment. The FEEDAP Panel cannot conclude on the potential of l-valine produced using E. coli CCTCC M2020321 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The endotoxin activity of the additive does not represent a hazard for users handling the additive when exposed by inhalation. The additive l-valine produced by fermentation using E. coli CCTCC M2020321 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
KW - amino acid
KW - efficacy
KW - Escherichia coli CCTCC M2020321
KW - l-valine
KW - nutritional additive
KW - safety
UR - http://www.scopus.com/inward/record.url?scp=85127169435&partnerID=8YFLogxK
U2 - 10.2903/j.efsa.2022.7163
DO - 10.2903/j.efsa.2022.7163
M3 - Journal article
C2 - 35228852
AN - SCOPUS:85127169435
VL - 20
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 2
M1 - e07163
ER -
ID: 320357274