Safety and Efficacy of l-histidine monohydrochloride monohydrate produced by fermentation using Escherichia coli KCCM 80212 as a feed additive for all animal species
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Safety and Efficacy of l-histidine monohydrochloride monohydrate produced by fermentation using Escherichia coli KCCM 80212 as a feed additive for all animal species. / Bampidis, Vasilios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Fašmon Durjava, Mojca; Kouba, Maryline; López-Alonso, Marta; López Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Cocconcelli, Pier Sandro; Glandorf, Boet; Herman, Lieve; Maradona, Miguel Prieto; Saarela, Maria; Anguita, Montserrat; Galobart, Jaume; Holczkencht, Orsolia; Manini, Paola; Pettenati, Elisa; Pizzo, Fabiola; Tarrés-Call, Jordi; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP).
In: EFSA Journal, Vol. 18, No. 11, e06287, 2020.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Safety and Efficacy of l-histidine monohydrochloride monohydrate produced by fermentation using Escherichia coli KCCM 80212 as a feed additive for all animal species
AU - Bampidis, Vasilios
AU - Azimonti, Giovanna
AU - Bastos, Maria de Lourdes
AU - Christensen, Henrik
AU - Dusemund, Birgit
AU - Fašmon Durjava, Mojca
AU - Kouba, Maryline
AU - López-Alonso, Marta
AU - López Puente, Secundino
AU - Marcon, Francesca
AU - Mayo, Baltasar
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Ramos, Fernando
AU - Sanz, Yolanda
AU - Villa, Roberto Edoardo
AU - Woutersen, Ruud
AU - Cocconcelli, Pier Sandro
AU - Glandorf, Boet
AU - Herman, Lieve
AU - Maradona, Miguel Prieto
AU - Saarela, Maria
AU - Anguita, Montserrat
AU - Galobart, Jaume
AU - Holczkencht, Orsolia
AU - Manini, Paola
AU - Pettenati, Elisa
AU - Pizzo, Fabiola
AU - Tarrés-Call, Jordi
AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
PY - 2020
Y1 - 2020
N2 - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-histidine monohydrochloride (HCl) monohydrate produced by fermentation using Escherichia coli KCCM 80212 when used as a nutritional additive in feed for all animal species. The production strain is genetically modified. The production strain and its recombinant DNA were not detected in the final product. l-Histidine HCl monohydrate manufactured by fermentation using E. coli KCCM 80212 does not give rise to any safety concern regarding the genetic modification. The use of l-histidine HCl monohydrate produced by fermentation using E. coli KCCM 80212 is safe for the target species when used as a nutritional additive to supplement the diet in appropriate amounts to cover the requirements, depending on the species, the physiological state of the animal, the performance level, the environmental conditions, the background amino acid composition of the unsupplemented diet and the status of some essential trace elements such as copper and zinc. l-Histidine HCl monohydrate produced using E. coli KCCM 80212 supplemented at levels appropriate for the requirements of the target species is considered safe for the consumer. l-Histidine HCl monohydrate produced by E. coli KCCM 80212 is a skin sensitiser. There is a risk for persons handling the additive from the exposure to endotoxins by inhalation. The additive under assessment is not irritant to skin or eyes. The use of l-histidine HCl monohydrate produced using E. coli KCCM 80212 in animal nutrition is not expected to represent a risk to the environment. l-Histidine HCl monohydrate is considered an efficacious source of the essential amino acid l-histidine for non-ruminant animal species. For the supplemental l-histidine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-histidine monohydrochloride (HCl) monohydrate produced by fermentation using Escherichia coli KCCM 80212 when used as a nutritional additive in feed for all animal species. The production strain is genetically modified. The production strain and its recombinant DNA were not detected in the final product. l-Histidine HCl monohydrate manufactured by fermentation using E. coli KCCM 80212 does not give rise to any safety concern regarding the genetic modification. The use of l-histidine HCl monohydrate produced by fermentation using E. coli KCCM 80212 is safe for the target species when used as a nutritional additive to supplement the diet in appropriate amounts to cover the requirements, depending on the species, the physiological state of the animal, the performance level, the environmental conditions, the background amino acid composition of the unsupplemented diet and the status of some essential trace elements such as copper and zinc. l-Histidine HCl monohydrate produced using E. coli KCCM 80212 supplemented at levels appropriate for the requirements of the target species is considered safe for the consumer. l-Histidine HCl monohydrate produced by E. coli KCCM 80212 is a skin sensitiser. There is a risk for persons handling the additive from the exposure to endotoxins by inhalation. The additive under assessment is not irritant to skin or eyes. The use of l-histidine HCl monohydrate produced using E. coli KCCM 80212 in animal nutrition is not expected to represent a risk to the environment. l-Histidine HCl monohydrate is considered an efficacious source of the essential amino acid l-histidine for non-ruminant animal species. For the supplemental l-histidine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
KW - amino acid
KW - Escherichia coli KCCM 80212
KW - feed additive
KW - l-histidine monohydrochloride monohydrate
KW - nutritional additive
KW - Safety
U2 - 10.2903/j.efsa.2020.6287
DO - 10.2903/j.efsa.2020.6287
M3 - Journal article
C2 - 33204314
AN - SCOPUS:85097068951
VL - 18
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 11
M1 - e06287
ER -
ID: 259990039