Antimicrobial Activity of Sertraline on Listeria monocytogenes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Antimicrobial Activity of Sertraline on Listeria monocytogenes. / Wang, Yidi; Li, Lili; Cai, Pingyao; Olsen, Rikke Heidemann; Peng, Shuai; Meng, Hecheng.

In: International Journal of Molecular Sciences, Vol. 24, No. 5, 4678, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wang, Y, Li, L, Cai, P, Olsen, RH, Peng, S & Meng, H 2023, 'Antimicrobial Activity of Sertraline on Listeria monocytogenes', International Journal of Molecular Sciences, vol. 24, no. 5, 4678. https://doi.org/10.3390/ijms24054678

APA

Wang, Y., Li, L., Cai, P., Olsen, R. H., Peng, S., & Meng, H. (2023). Antimicrobial Activity of Sertraline on Listeria monocytogenes. International Journal of Molecular Sciences, 24(5), [4678]. https://doi.org/10.3390/ijms24054678

Vancouver

Wang Y, Li L, Cai P, Olsen RH, Peng S, Meng H. Antimicrobial Activity of Sertraline on Listeria monocytogenes. International Journal of Molecular Sciences. 2023;24(5). 4678. https://doi.org/10.3390/ijms24054678

Author

Wang, Yidi ; Li, Lili ; Cai, Pingyao ; Olsen, Rikke Heidemann ; Peng, Shuai ; Meng, Hecheng. / Antimicrobial Activity of Sertraline on Listeria monocytogenes. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 5.

Bibtex

@article{8a370dba3bd74f1ba32bc6b211f60d93,
title = "Antimicrobial Activity of Sertraline on Listeria monocytogenes",
abstract = "We explored the antimicrobial activity of sertraline on Listeria monocytogenes and further investigated the effects of sertraline on biofilm formation and the virulence gene expression of L. monocytogenes. The minimum inhibitory concentration and minimum bactericidal concentration for sertraline against L. monocytogenes were in the range of 16–32 μg/mL and 64 μg/mL, respectively. Sertraline-dependent damage of the cell membrane and a decrease in intracellular ATP and pHin in L. monocytogenes were observed. In addition, sertraline reduced the biofilm formation efficiency of the L. monocytogenes strains. Importantly, low concentrations (0.1 μg/mL and 1 μg/mL) of sertraline significantly down-regulated the expression levels of various L. monocytogens virulence genes (prfA, actA, degU, flaA, sigB, ltrC and sufS). These results collectively suggest a role of sertraline for the control of L. monocytogenes in the food industry.",
keywords = "antimicrobial activity, biofilm, Listeria monocytogenes, sertraline, virulence",
author = "Yidi Wang and Lili Li and Pingyao Cai and Olsen, {Rikke Heidemann} and Shuai Peng and Hecheng Meng",
note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
doi = "10.3390/ijms24054678",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Antimicrobial Activity of Sertraline on Listeria monocytogenes

AU - Wang, Yidi

AU - Li, Lili

AU - Cai, Pingyao

AU - Olsen, Rikke Heidemann

AU - Peng, Shuai

AU - Meng, Hecheng

N1 - Publisher Copyright: © 2023 by the authors.

PY - 2023

Y1 - 2023

N2 - We explored the antimicrobial activity of sertraline on Listeria monocytogenes and further investigated the effects of sertraline on biofilm formation and the virulence gene expression of L. monocytogenes. The minimum inhibitory concentration and minimum bactericidal concentration for sertraline against L. monocytogenes were in the range of 16–32 μg/mL and 64 μg/mL, respectively. Sertraline-dependent damage of the cell membrane and a decrease in intracellular ATP and pHin in L. monocytogenes were observed. In addition, sertraline reduced the biofilm formation efficiency of the L. monocytogenes strains. Importantly, low concentrations (0.1 μg/mL and 1 μg/mL) of sertraline significantly down-regulated the expression levels of various L. monocytogens virulence genes (prfA, actA, degU, flaA, sigB, ltrC and sufS). These results collectively suggest a role of sertraline for the control of L. monocytogenes in the food industry.

AB - We explored the antimicrobial activity of sertraline on Listeria monocytogenes and further investigated the effects of sertraline on biofilm formation and the virulence gene expression of L. monocytogenes. The minimum inhibitory concentration and minimum bactericidal concentration for sertraline against L. monocytogenes were in the range of 16–32 μg/mL and 64 μg/mL, respectively. Sertraline-dependent damage of the cell membrane and a decrease in intracellular ATP and pHin in L. monocytogenes were observed. In addition, sertraline reduced the biofilm formation efficiency of the L. monocytogenes strains. Importantly, low concentrations (0.1 μg/mL and 1 μg/mL) of sertraline significantly down-regulated the expression levels of various L. monocytogens virulence genes (prfA, actA, degU, flaA, sigB, ltrC and sufS). These results collectively suggest a role of sertraline for the control of L. monocytogenes in the food industry.

KW - antimicrobial activity

KW - biofilm

KW - Listeria monocytogenes

KW - sertraline

KW - virulence

U2 - 10.3390/ijms24054678

DO - 10.3390/ijms24054678

M3 - Journal article

C2 - 36902108

AN - SCOPUS:85149816779

VL - 24

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 5

M1 - 4678

ER -

ID: 340117620