Citrus flavonoids, β-Glucan and organic acid feed additives decrease relative risk during Yersinia ruckeri O1 biotype 2 infection of rainbow trout (Oncorhynchus mykiss)
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Citrus flavonoids, β-Glucan and organic acid feed additives decrease relative risk during Yersinia ruckeri O1 biotype 2 infection of rainbow trout (Oncorhynchus mykiss). / Villumsen, Kasper Rømer; Ohtani, Maki; Forberg, Torunn; Tinsley, John; Boye, Mette; Bojesen, Anders M.
In: PeerJ, Vol. 2020, No. 3, e8706, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Citrus flavonoids, β-Glucan and organic acid feed additives decrease relative risk during Yersinia ruckeri O1 biotype 2 infection of rainbow trout (Oncorhynchus mykiss)
AU - Villumsen, Kasper Rømer
AU - Ohtani, Maki
AU - Forberg, Torunn
AU - Tinsley, John
AU - Boye, Mette
AU - Bojesen, Anders M.
PY - 2020
Y1 - 2020
N2 - Whether through direct supplementation of bacteria or by prebiotic supplementation thought to favour subsets of bacteria, modulation of gut microbiota constitutes an important and promising alternative to the use of prophylactic and growth promoting antibiotics in worldwide aquaculture. We fed a commercial base feed, alone or supplemented with either proprietary β-glucan, β-glucan and organic acids, citrus flavonoid or yeast cell wall supplements, to rainbow trout over a period of four weeks. Fish from each feed group were then subjected to experimental, waterborne infection with Yersinia ruckeri O1 biotype 2. Following experimental feeding, the β-glucan and organic acids supplemented group showed significantly improved feed conversion and lipid efficiency ratios. Furthermore, the β-glucan, β-glucan and organic acids and citrus flavonoid supplements proved to significantly reduce the risk of mortality in rainbow trout during experimental infection as shown by hazard ratio analysis. Resulting in 33.2%, 30.6% and 30.5% reduction in risk relative to the non-supplemented base feed, respectively, these three supplements show a promising potential either as stand-alone feed supplements, or as components in complex feed formulations.
AB - Whether through direct supplementation of bacteria or by prebiotic supplementation thought to favour subsets of bacteria, modulation of gut microbiota constitutes an important and promising alternative to the use of prophylactic and growth promoting antibiotics in worldwide aquaculture. We fed a commercial base feed, alone or supplemented with either proprietary β-glucan, β-glucan and organic acids, citrus flavonoid or yeast cell wall supplements, to rainbow trout over a period of four weeks. Fish from each feed group were then subjected to experimental, waterborne infection with Yersinia ruckeri O1 biotype 2. Following experimental feeding, the β-glucan and organic acids supplemented group showed significantly improved feed conversion and lipid efficiency ratios. Furthermore, the β-glucan, β-glucan and organic acids and citrus flavonoid supplements proved to significantly reduce the risk of mortality in rainbow trout during experimental infection as shown by hazard ratio analysis. Resulting in 33.2%, 30.6% and 30.5% reduction in risk relative to the non-supplemented base feed, respectively, these three supplements show a promising potential either as stand-alone feed supplements, or as components in complex feed formulations.
KW - Aquaculture
KW - Enteric redmouth disease
KW - Feed
KW - Feed additives
KW - Infection model
KW - Oncorhynchus mykiss
KW - Prebiotics
KW - Rainbow trout
KW - Risk
KW - Yersinia ruckeri
U2 - 10.7717/peerj.8706
DO - 10.7717/peerj.8706
M3 - Journal article
C2 - 32181057
AN - SCOPUS:85083507490
VL - 2020
JO - PeerJ
JF - PeerJ
SN - 2167-8359
IS - 3
M1 - e8706
ER -
ID: 240148628