Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea. / Rydal, Martin Peter; Gambino, Michela; Jørgensen, Claus Bøttcher; Poulsen, Louise Ladefoged; Brøndsted, Lone; Nielsen, Jens Peter.

In: BMC Veterinary Research, Vol. 18, 382, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rydal, MP, Gambino, M, Jørgensen, CB, Poulsen, LL, Brøndsted, L & Nielsen, JP 2022, 'Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea', BMC Veterinary Research, vol. 18, 382. https://doi.org/10.1186/s12917-022-03474-3

APA

Rydal, M. P., Gambino, M., Jørgensen, C. B., Poulsen, L. L., Brøndsted, L., & Nielsen, J. P. (2022). Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea. BMC Veterinary Research, 18, [382]. https://doi.org/10.1186/s12917-022-03474-3

Vancouver

Rydal MP, Gambino M, Jørgensen CB, Poulsen LL, Brøndsted L, Nielsen JP. Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea. BMC Veterinary Research. 2022;18. 382. https://doi.org/10.1186/s12917-022-03474-3

Author

Rydal, Martin Peter ; Gambino, Michela ; Jørgensen, Claus Bøttcher ; Poulsen, Louise Ladefoged ; Brøndsted, Lone ; Nielsen, Jens Peter. / Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea. In: BMC Veterinary Research. 2022 ; Vol. 18.

Bibtex

@article{b54522a31e3a49e398b89a19a1641705,
title = "Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea",
abstract = "Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 108 CFU or 1010 CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.",
keywords = "Diarrhea, Enterotoxigenic Escherichia coli, Experimental infection, F4 fimbriae, Genetic marker, Inoculum dose, Piglet, Post-weaning",
author = "Rydal, {Martin Peter} and Michela Gambino and J{\o}rgensen, {Claus B{\o}ttcher} and Poulsen, {Louise Ladefoged} and Lone Br{\o}ndsted and Nielsen, {Jens Peter}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1186/s12917-022-03474-3",
language = "English",
volume = "18",
journal = "B M C Veterinary Research",
issn = "1746-6148",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea

AU - Rydal, Martin Peter

AU - Gambino, Michela

AU - Jørgensen, Claus Bøttcher

AU - Poulsen, Louise Ladefoged

AU - Brøndsted, Lone

AU - Nielsen, Jens Peter

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 108 CFU or 1010 CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.

AB - Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 108 CFU or 1010 CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.

KW - Diarrhea

KW - Enterotoxigenic Escherichia coli

KW - Experimental infection

KW - F4 fimbriae

KW - Genetic marker

KW - Inoculum dose

KW - Piglet

KW - Post-weaning

U2 - 10.1186/s12917-022-03474-3

DO - 10.1186/s12917-022-03474-3

M3 - Journal article

C2 - 36320033

AN - SCOPUS:85140998201

VL - 18

JO - B M C Veterinary Research

JF - B M C Veterinary Research

SN - 1746-6148

M1 - 382

ER -

ID: 330935004