TY - JOUR

T1 - Health-related quality of life in Iranian patients with multiple sclerosis

T2 - a cross-cultural study

AU - Pakpour, Amir H.

AU - Yekaninejad, Mir Saeed

AU - Mohammadi, Nastaran Keshavarz

AU - Molsted, Stig

AU - Zarei, Fatemeh

AU - Patti, Francesco

AU - Harrison, Adrian

PY - 2010/1/8

Y1 - 2010/1/8

N2 - BACKGROUND AND PURPOSE: This study aimed to evaluate aspects of health-related quality of life (HRQoL) of patients with multiple sclerosis (MS) who live in Tehran and to compare data with evaluations of both the general population and MS patients in other countries.MATERIAL AND METHODS: One hundred and forty patients with MS, yet without severe comorbidity, were selected according to convenience sampling in a cross-sectional study. Data were collected by means of the SF-36 questionnaire and Beck Depression Inventory (BDI). The Expanded Disability Status Scale of Kurtzke (EDSS) and Mini Mental State Examination were recorded for all patients.RESULTS: The mean age of the participants was 34.7 years. For all SF-36 scales, MS patients were found to have lower scores, after adjustment for sex and age, compared with the general population. BDI and EDSS scores were significantly and negatively correlated with all of the SF-36 scales. Moreover, the BDI and EDSS were found to be positively correlated with one another (r = 0.415, p < 0.01).CONCLUSIONS: The findings strongly confirm that patients with MS suffer from poor HRQoL. Depression had a strong effect on HRQoL and in order to improve HRQoL in MS patients the prevention and treatment of depression is vital.

AB - BACKGROUND AND PURPOSE: This study aimed to evaluate aspects of health-related quality of life (HRQoL) of patients with multiple sclerosis (MS) who live in Tehran and to compare data with evaluations of both the general population and MS patients in other countries.MATERIAL AND METHODS: One hundred and forty patients with MS, yet without severe comorbidity, were selected according to convenience sampling in a cross-sectional study. Data were collected by means of the SF-36 questionnaire and Beck Depression Inventory (BDI). The Expanded Disability Status Scale of Kurtzke (EDSS) and Mini Mental State Examination were recorded for all patients.RESULTS: The mean age of the participants was 34.7 years. For all SF-36 scales, MS patients were found to have lower scores, after adjustment for sex and age, compared with the general population. BDI and EDSS scores were significantly and negatively correlated with all of the SF-36 scales. Moreover, the BDI and EDSS were found to be positively correlated with one another (r = 0.415, p < 0.01).CONCLUSIONS: The findings strongly confirm that patients with MS suffer from poor HRQoL. Depression had a strong effect on HRQoL and in order to improve HRQoL in MS patients the prevention and treatment of depression is vital.

KW - Activities of Daily Living

KW - Adult

KW - Comorbidity

KW - Cross-Cultural Comparison

KW - Cross-Sectional Studies

KW - Depression

KW - Disability Evaluation

KW - Female

KW - Health Status

KW - Humans

KW - Iran

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Quality of Life

KW - Self Concept

KW - Severity of Illness Index

KW - Surveys and Questionnaires

KW - Comparative Study

KW - Journal Article

M3 - Journal article

C2 - 20054754

VL - 43

SP - 517

EP - 526

JO - Neurologia i Neurochirurgia Polska

JF - Neurologia i Neurochirurgia Polska

SN - 0028-3843

IS - 6

ER -