Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal? / Williams, Andrew Richard.

In: Parasitology, Vol. 138, No. 5, 2011, p. 547-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Williams, AR 2011, 'Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal?', Parasitology, vol. 138, no. 5, pp. 547-56. https://doi.org/10.1017/S0031182010001654

APA

Williams, A. R. (2011). Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal? Parasitology, 138(5), 547-56. https://doi.org/10.1017/S0031182010001654

Vancouver

Williams AR. Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal? Parasitology. 2011;138(5):547-56. https://doi.org/10.1017/S0031182010001654

Author

Williams, Andrew Richard. / Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal?. In: Parasitology. 2011 ; Vol. 138, No. 5. pp. 547-56.

Bibtex

@article{0828d45aae1349cd92f2392f2ae61da2,
title = "Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal?",
abstract = "Nematode parasitism is a severe impediment to sustainable and profitable sheep production in many countries in the world. Parasite resistance to anthelmintic treatment and consumer demand for organic agricultural products has led to much research into harnessing natural immunity as a long-term control measure. However, there is evidence that many of the clinical signs of nematode infection in sheep are due to immune-mediated pathology rather than direct effects of the parasite. Therefore, the desirability of promoting a strong natural immunity in sheep has been questioned. This review attempts to clarify some of the arguments for and against promoting strong natural immunity, particularly through selective breeding of parasite-resistant animals. It is concluded that the detrimental effects of immune-mediated pathology are outweighed by epidemiological and welfare benefits. Thus, control of nematode parasites through selection of naturally resistant sheep is a sustainable and desirable objective.",
author = "Williams, {Andrew Richard}",
year = "2011",
doi = "10.1017/S0031182010001654",
language = "English",
volume = "138",
pages = "547--56",
journal = "Parasitology",
issn = "0031-1820",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Immune-mediated pathology of nematode infection in sheep--is immunity beneficial to the animal?

AU - Williams, Andrew Richard

PY - 2011

Y1 - 2011

N2 - Nematode parasitism is a severe impediment to sustainable and profitable sheep production in many countries in the world. Parasite resistance to anthelmintic treatment and consumer demand for organic agricultural products has led to much research into harnessing natural immunity as a long-term control measure. However, there is evidence that many of the clinical signs of nematode infection in sheep are due to immune-mediated pathology rather than direct effects of the parasite. Therefore, the desirability of promoting a strong natural immunity in sheep has been questioned. This review attempts to clarify some of the arguments for and against promoting strong natural immunity, particularly through selective breeding of parasite-resistant animals. It is concluded that the detrimental effects of immune-mediated pathology are outweighed by epidemiological and welfare benefits. Thus, control of nematode parasites through selection of naturally resistant sheep is a sustainable and desirable objective.

AB - Nematode parasitism is a severe impediment to sustainable and profitable sheep production in many countries in the world. Parasite resistance to anthelmintic treatment and consumer demand for organic agricultural products has led to much research into harnessing natural immunity as a long-term control measure. However, there is evidence that many of the clinical signs of nematode infection in sheep are due to immune-mediated pathology rather than direct effects of the parasite. Therefore, the desirability of promoting a strong natural immunity in sheep has been questioned. This review attempts to clarify some of the arguments for and against promoting strong natural immunity, particularly through selective breeding of parasite-resistant animals. It is concluded that the detrimental effects of immune-mediated pathology are outweighed by epidemiological and welfare benefits. Thus, control of nematode parasites through selection of naturally resistant sheep is a sustainable and desirable objective.

U2 - 10.1017/S0031182010001654

DO - 10.1017/S0031182010001654

M3 - Journal article

C2 - 21272412

VL - 138

SP - 547

EP - 556

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 5

ER -

ID: 44099869