Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

Research output: Contribution to journal › Journal article › Research › peer-review

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Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes. / Williams, Andrew Richard; Zakutansky, Sara E; Miura, Kazutoyo; Dicks, Matthew J D; Churcher, Thomas S; Jewell, Kerry E; Vaughan, Aisling M; Turner, Alison V; Kapulu, Melissa C; Michel, Kristin; Long, Carole A; Sinden, Robert E; Hill, Adrian V S; Draper, Simon J; Biswas, Sumi.

In: International Journal for Parasitology, Vol. 43, No. 11, 18.07.2013, p. 869-874.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Williams, AR, Zakutansky, SE, Miura, K, Dicks, MJD, Churcher, TS, Jewell, KE, Vaughan, AM, Turner, AV, Kapulu, MC, Michel, K, Long, CA, Sinden, RE, Hill, AVS, Draper, SJ & Biswas, S 2013, 'Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes', International Journal for Parasitology, vol. 43, no. 11, pp. 869-874. https://doi.org/10.1016/j.ijpara.2013.06.004

APA

Williams, A. R., Zakutansky, S. E., Miura, K., Dicks, M. J. D., Churcher, T. S., Jewell, K. E., Vaughan, A. M., Turner, A. V., Kapulu, M. C., Michel, K., Long, C. A., Sinden, R. E., Hill, A. V. S., Draper, S. J., & Biswas, S. (2013). Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes. International Journal for Parasitology, 43(11), 869-874. https://doi.org/10.1016/j.ijpara.2013.06.004

Vancouver

Williams AR, Zakutansky SE, Miura K, Dicks MJD, Churcher TS, Jewell KE et al. Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes. International Journal for Parasitology. 2013 Jul 18;43(11):869-874. https://doi.org/10.1016/j.ijpara.2013.06.004

Author

Williams, Andrew Richard ; Zakutansky, Sara E ; Miura, Kazutoyo ; Dicks, Matthew J D ; Churcher, Thomas S ; Jewell, Kerry E ; Vaughan, Aisling M ; Turner, Alison V ; Kapulu, Melissa C ; Michel, Kristin ; Long, Carole A ; Sinden, Robert E ; Hill, Adrian V S ; Draper, Simon J ; Biswas, Sumi. / Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes. In: International Journal for Parasitology. 2013 ; Vol. 43, No. 11. pp. 869-874.

Bibtex

@article{cca94bee1e6a4e4eae76d6422dce0e63,
title = "Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes",
abstract = "The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.",
author = "Williams, {Andrew Richard} and Zakutansky, {Sara E} and Kazutoyo Miura and Dicks, {Matthew J D} and Churcher, {Thomas S} and Jewell, {Kerry E} and Vaughan, {Aisling M} and Turner, {Alison V} and Kapulu, {Melissa C} and Kristin Michel and Long, {Carole A} and Sinden, {Robert E} and Hill, {Adrian V S} and Draper, {Simon J} and Sumi Biswas",
note = "Copyright {\textcopyright} 2013. Published by Elsevier Ltd.",
year = "2013",
month = jul,
day = "18",
doi = "10.1016/j.ijpara.2013.06.004",
language = "English",
volume = "43",
pages = "869--874",
journal = "International Journal for Parasitology",
issn = "0020-7519",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

AU - Williams, Andrew Richard

AU - Zakutansky, Sara E

AU - Miura, Kazutoyo

AU - Dicks, Matthew J D

AU - Churcher, Thomas S

AU - Jewell, Kerry E

AU - Vaughan, Aisling M

AU - Turner, Alison V

AU - Kapulu, Melissa C

AU - Michel, Kristin

AU - Long, Carole A

AU - Sinden, Robert E

AU - Hill, Adrian V S

AU - Draper, Simon J

AU - Biswas, Sumi

N1 - Copyright © 2013. Published by Elsevier Ltd.

PY - 2013/7/18

Y1 - 2013/7/18

N2 - The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.

AB - The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.

U2 - 10.1016/j.ijpara.2013.06.004

DO - 10.1016/j.ijpara.2013.06.004

M3 - Journal article

C2 - 23872520

VL - 43

SP - 869

EP - 874

JO - International Journal for Parasitology

JF - International Journal for Parasitology

SN - 0020-7519

IS - 11

ER -

ID: 48013191