Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Short Communication : Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep. / Williams, Andrew Richard.
In: Journal of Parasitology Research, Vol. 2012, 2012, p. 569287.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Short Communication
T2 - Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
AU - Williams, Andrew Richard
PY - 2012
Y1 - 2012
N2 - Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells and globule leukocytes in the abomasum, and that all three of these parameters are negatively associated with numbers of adult Teladorsagia circumcincta during the challenge of immune sheep. It is suggested that bradykinin either stimulates the degranulation of mast cells, or is released during this degranulation process, or both. Multiple regression showed that almost 60% of the variation of in adult T. circumcincta could be explained by two variables, bradykinin and T. circumcincta-specific IgG(1) in plasma. This provides further evidence that bradykinin may be a mechanism of protective immunity in sheep, although its involvement in asthma and other allergic disorders raises questions about its role in unwanted immunopathology.
AB - Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells and globule leukocytes in the abomasum, and that all three of these parameters are negatively associated with numbers of adult Teladorsagia circumcincta during the challenge of immune sheep. It is suggested that bradykinin either stimulates the degranulation of mast cells, or is released during this degranulation process, or both. Multiple regression showed that almost 60% of the variation of in adult T. circumcincta could be explained by two variables, bradykinin and T. circumcincta-specific IgG(1) in plasma. This provides further evidence that bradykinin may be a mechanism of protective immunity in sheep, although its involvement in asthma and other allergic disorders raises questions about its role in unwanted immunopathology.
U2 - 10.1155/2012/569287
DO - 10.1155/2012/569287
M3 - Journal article
C2 - 22523641
VL - 2012
SP - 569287
JO - Journal of Parasitology Research
JF - Journal of Parasitology Research
SN - 2090-0023
ER -
ID: 44099841