Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans

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Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans. / Ropiak, Honorata M; Desrues, Olivier; Williams, Andrew Richard; Ramsay, Aina; Mueller-Harvey, Irene; Thamsborg, Stig Milan.

In: Journal of Agricultural and Food Chemistry, Vol. 64, No. 46, 23.11.2016, p. 8795-8805.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ropiak, HM, Desrues, O, Williams, AR, Ramsay, A, Mueller-Harvey, I & Thamsborg, SM 2016, 'Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans', Journal of Agricultural and Food Chemistry, vol. 64, no. 46, pp. 8795-8805. https://doi.org/10.1021/acs.jafc.6b03842

APA

Ropiak, H. M., Desrues, O., Williams, A. R., Ramsay, A., Mueller-Harvey, I., & Thamsborg, S. M. (2016). Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 64(46), 8795-8805. https://doi.org/10.1021/acs.jafc.6b03842

Vancouver

Ropiak HM, Desrues O, Williams AR, Ramsay A, Mueller-Harvey I, Thamsborg SM. Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans. Journal of Agricultural and Food Chemistry. 2016 Nov 23;64(46):8795-8805. https://doi.org/10.1021/acs.jafc.6b03842

Author

Ropiak, Honorata M ; Desrues, Olivier ; Williams, Andrew Richard ; Ramsay, Aina ; Mueller-Harvey, Irene ; Thamsborg, Stig Milan. / Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans. In: Journal of Agricultural and Food Chemistry. 2016 ; Vol. 64, No. 46. pp. 8795-8805.

Bibtex

@article{0d69026c6d7f4acab7ffca11ac2027a6,
title = "Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans",
abstract = "Parasitic gastrointestinal nematodes (GIN) of livestock are increasingly developing resistance to synthetic nematocidal drugs. Moreover, the use of nematocides can induce ecotoxicity by affecting free-living nematodes. Condensed tannins (CT) are a structurally diverse group of bioactive plant compounds possessing anthelmintic activity against GIN. We investigated the relationship between the chemical structure of contrasting, purified CT and nematocidal effects using Caenorhabditis elegans. We also explored whether the nematocidal activity of CT could synergize with trans-cinnamaldehyde (CIN). A nonsignificant correlation was evident between the ability of CT fractions to inhibit C. elegans motility and the molar proportion of prodelphinidin subunits in purified CT samples. Synergistic inhibition of motility was achieved by combinations of CT and CIN. Galloylation of procyanidins was also a key factor for synergy. To increase the nematocidal effect of CT, plant sources containing CT with specific structural features could be selected and combined with compounds acting in synergy.",
author = "Ropiak, {Honorata M} and Olivier Desrues and Williams, {Andrew Richard} and Aina Ramsay and Irene Mueller-Harvey and Thamsborg, {Stig Milan}",
year = "2016",
month = nov,
day = "23",
doi = "10.1021/acs.jafc.6b03842",
language = "English",
volume = "64",
pages = "8795--8805",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "46",

}

RIS

TY - JOUR

T1 - Structure-activity relationship of condensed tannins and synergism with trans-cinnamaldehyde against Caenorhabditis elegans

AU - Ropiak, Honorata M

AU - Desrues, Olivier

AU - Williams, Andrew Richard

AU - Ramsay, Aina

AU - Mueller-Harvey, Irene

AU - Thamsborg, Stig Milan

PY - 2016/11/23

Y1 - 2016/11/23

N2 - Parasitic gastrointestinal nematodes (GIN) of livestock are increasingly developing resistance to synthetic nematocidal drugs. Moreover, the use of nematocides can induce ecotoxicity by affecting free-living nematodes. Condensed tannins (CT) are a structurally diverse group of bioactive plant compounds possessing anthelmintic activity against GIN. We investigated the relationship between the chemical structure of contrasting, purified CT and nematocidal effects using Caenorhabditis elegans. We also explored whether the nematocidal activity of CT could synergize with trans-cinnamaldehyde (CIN). A nonsignificant correlation was evident between the ability of CT fractions to inhibit C. elegans motility and the molar proportion of prodelphinidin subunits in purified CT samples. Synergistic inhibition of motility was achieved by combinations of CT and CIN. Galloylation of procyanidins was also a key factor for synergy. To increase the nematocidal effect of CT, plant sources containing CT with specific structural features could be selected and combined with compounds acting in synergy.

AB - Parasitic gastrointestinal nematodes (GIN) of livestock are increasingly developing resistance to synthetic nematocidal drugs. Moreover, the use of nematocides can induce ecotoxicity by affecting free-living nematodes. Condensed tannins (CT) are a structurally diverse group of bioactive plant compounds possessing anthelmintic activity against GIN. We investigated the relationship between the chemical structure of contrasting, purified CT and nematocidal effects using Caenorhabditis elegans. We also explored whether the nematocidal activity of CT could synergize with trans-cinnamaldehyde (CIN). A nonsignificant correlation was evident between the ability of CT fractions to inhibit C. elegans motility and the molar proportion of prodelphinidin subunits in purified CT samples. Synergistic inhibition of motility was achieved by combinations of CT and CIN. Galloylation of procyanidins was also a key factor for synergy. To increase the nematocidal effect of CT, plant sources containing CT with specific structural features could be selected and combined with compounds acting in synergy.

U2 - 10.1021/acs.jafc.6b03842

DO - 10.1021/acs.jafc.6b03842

M3 - Journal article

C2 - 27796095

VL - 64

SP - 8795

EP - 8805

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 46

ER -

ID: 169944917