The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody. / Douglas, Alexander D; Williams, Andrew Richard; Illingworth, Joseph J; Kamuyu, Gathoni; Biswas, Sumi; Goodman, Anna L; Wyllie, David H; Crosnier, Cécile; Miura, Kazutoyo; Wright, Gavin J; Long, Carole A; Osier, Faith H; Marsh, Kevin; Turner, Alison V; Hill, Adrian V S; Draper, Simon J.

In: Nature Communications, Vol. 2, 2011, p. 601.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Douglas, AD, Williams, AR, Illingworth, JJ, Kamuyu, G, Biswas, S, Goodman, AL, Wyllie, DH, Crosnier, C, Miura, K, Wright, GJ, Long, CA, Osier, FH, Marsh, K, Turner, AV, Hill, AVS & Draper, SJ 2011, 'The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody', Nature Communications, vol. 2, pp. 601. https://doi.org/10.1038/ncomms1615

APA

Douglas, A. D., Williams, A. R., Illingworth, J. J., Kamuyu, G., Biswas, S., Goodman, A. L., Wyllie, D. H., Crosnier, C., Miura, K., Wright, G. J., Long, C. A., Osier, F. H., Marsh, K., Turner, A. V., Hill, A. V. S., & Draper, S. J. (2011). The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody. Nature Communications, 2, 601. https://doi.org/10.1038/ncomms1615

Vancouver

Douglas AD, Williams AR, Illingworth JJ, Kamuyu G, Biswas S, Goodman AL et al. The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody. Nature Communications. 2011;2:601. https://doi.org/10.1038/ncomms1615

Author

Douglas, Alexander D ; Williams, Andrew Richard ; Illingworth, Joseph J ; Kamuyu, Gathoni ; Biswas, Sumi ; Goodman, Anna L ; Wyllie, David H ; Crosnier, Cécile ; Miura, Kazutoyo ; Wright, Gavin J ; Long, Carole A ; Osier, Faith H ; Marsh, Kevin ; Turner, Alison V ; Hill, Adrian V S ; Draper, Simon J. / The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody. In: Nature Communications. 2011 ; Vol. 2. pp. 601.

Bibtex

@article{1d4f03e9d4074ade8afc59e8eba1bf7c,
title = "The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody",
abstract = "Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length P. falciparum reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutralizing vaccine-induced antibodies, out-performing all other antigens delivered by the same vaccine platform. We find that, despite being susceptible to antibody, PfRH5 is unlikely to be under substantial immune selection pressure; there is minimal acquisition of anti-PfRH5 IgG antibodies in malaria-exposed Kenyans. These data challenge the widespread beliefs that any merozoite antigen that is highly susceptible to immune attack would be subject to significant levels of antigenic polymorphism, and that erythrocyte invasion by P. falciparum is a degenerate process involving a series of parallel redundant pathways.",
author = "Douglas, {Alexander D} and Williams, {Andrew Richard} and Illingworth, {Joseph J} and Gathoni Kamuyu and Sumi Biswas and Goodman, {Anna L} and Wyllie, {David H} and C{\'e}cile Crosnier and Kazutoyo Miura and Wright, {Gavin J} and Long, {Carole A} and Osier, {Faith H} and Kevin Marsh and Turner, {Alison V} and Hill, {Adrian V S} and Draper, {Simon J}",
year = "2011",
doi = "10.1038/ncomms1615",
language = "English",
volume = "2",
pages = "601",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

AU - Douglas, Alexander D

AU - Williams, Andrew Richard

AU - Illingworth, Joseph J

AU - Kamuyu, Gathoni

AU - Biswas, Sumi

AU - Goodman, Anna L

AU - Wyllie, David H

AU - Crosnier, Cécile

AU - Miura, Kazutoyo

AU - Wright, Gavin J

AU - Long, Carole A

AU - Osier, Faith H

AU - Marsh, Kevin

AU - Turner, Alison V

AU - Hill, Adrian V S

AU - Draper, Simon J

PY - 2011

Y1 - 2011

N2 - Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length P. falciparum reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutralizing vaccine-induced antibodies, out-performing all other antigens delivered by the same vaccine platform. We find that, despite being susceptible to antibody, PfRH5 is unlikely to be under substantial immune selection pressure; there is minimal acquisition of anti-PfRH5 IgG antibodies in malaria-exposed Kenyans. These data challenge the widespread beliefs that any merozoite antigen that is highly susceptible to immune attack would be subject to significant levels of antigenic polymorphism, and that erythrocyte invasion by P. falciparum is a degenerate process involving a series of parallel redundant pathways.

AB - Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length P. falciparum reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutralizing vaccine-induced antibodies, out-performing all other antigens delivered by the same vaccine platform. We find that, despite being susceptible to antibody, PfRH5 is unlikely to be under substantial immune selection pressure; there is minimal acquisition of anti-PfRH5 IgG antibodies in malaria-exposed Kenyans. These data challenge the widespread beliefs that any merozoite antigen that is highly susceptible to immune attack would be subject to significant levels of antigenic polymorphism, and that erythrocyte invasion by P. falciparum is a degenerate process involving a series of parallel redundant pathways.

U2 - 10.1038/ncomms1615

DO - 10.1038/ncomms1615

M3 - Journal article

C2 - 22186897

VL - 2

SP - 601

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

ID: 44099680