TY - JOUR

T1 - Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed.


T2 - Part 10: Quinolones: flumequine and oxolinic acid

AU - EFSA Panel on Biological Hazards (BIOHAZ), null

AU - Koutsoumanis, Konstantinos

AU - Allende, Ana

AU - Alvarez-Ordóñez, Avelino

AU - Bolton, Declan

AU - Bover-Cid, Sara

AU - Chemaly, Marianne

AU - Davies, Robert

AU - De Cesare, Alessandra

AU - Herman, Lieve

AU - Hilbert, Friederike

AU - Lindqvist, Roland

AU - Nauta, Maarten

AU - Ru, Giuseppe

AU - Simmons, Marion

AU - Skandamis, Panagiotis

AU - Suffredini, Elisabetta

AU - Andersson, Dan I

AU - Bampidis, Vasileios

AU - Bengtsson-Palme, Johan

AU - Bouchard, Damien

AU - Ferran, Aude

AU - Kouba, Maryline

AU - López Puente, Secundino

AU - López-Alonso, Marta

AU - Nielsen, Søren Saxmose

AU - Pechová, Alena

AU - Petkova, Mariana

AU - Girault, Sebastien

AU - Broglia, Alessandro

AU - Guerra, Beatriz

AU - Innocenti, Matteo Lorenzo

AU - Liébana, Ernesto

AU - López-Gálvez, Gloria

AU - Manini, Paola

AU - Stella, Pietro

AU - Peixe, Luisa

PY - 2021/10/26

Y1 - 2021/10/26

N2 - Abstract The specific concentrations of flumequine and oxolinic acid in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data are available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. No suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these antimicrobials.

AB - Abstract The specific concentrations of flumequine and oxolinic acid in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data are available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. No suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these antimicrobials.

KW - flumequine

KW - oxolinic acid

KW - antimicrobial resistance

KW - sub-inhibitory concentration

KW - growth promotion

KW - yield increase

KW - food-producing animals

U2 - 10.2903/j.efsa.2021.6862

DO - 10.2903/j.efsa.2021.6862

M3 - Journal article

C2 - 34729090

VL - 19

SP - 1

EP - 18

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 10

M1 - e06862

ER -