TY - JOUR

T1 - Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 13: Diaminopyrimidines: trimethoprim

AU - EFSA Panel on Biological Hazards (BIOHAZ), null

AU - Koutsoumanis, Konstantinos

AU - Allende, Ana

AU - Alvarez-Ordóñez, Avelino

AU - Bolton, Declan

AU - Bover-Cid, Sara

AU - Chemaly, Marianne

AU - Davies, Robert

AU - De Cesare, Alessandra

AU - Herman, Lieve

AU - Hilbert, Friederike

AU - Lindqvist, Roland

AU - Nauta, Maarten

AU - Ru, Giuseppe

AU - Simmons, Marion

AU - Skandamis, Panagiotis

AU - Suffredini, Elisabetta

AU - Andersson, Dan I

AU - Bampidis, Vasileios

AU - Bengtsson-Palme, Johan

AU - Bouchard, Damien

AU - Ferran, Aude

AU - Kouba, Maryline

AU - López Puente, Secundino

AU - López-Alonso, Marta

AU - Nielsen, Søren Saxmose

AU - Pechová, Alena

AU - Petkova, Mariana

AU - Girault, Sebastien

AU - Broglia, Alessandro

AU - Guerra, Beatriz

AU - Innocenti, Matteo Lorenzo

AU - Liébana, Ernesto

AU - López-Gálvez, Gloria

AU - Manini, Paola

AU - Stella, Pietro

AU - Peixe, Luisa

PY - 2021/10/26

Y1 - 2021/10/26

N2 - Abstract The specific concentrations of trimethoprim in non-target feed for food-producing animals below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for trimethoprim was estimated. Uncertainties and data gaps associated to the levels reported were addressed. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. No suitable data for the assessment were available. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for trimethoprim.

AB - Abstract The specific concentrations of trimethoprim in non-target feed for food-producing animals below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for trimethoprim was estimated. Uncertainties and data gaps associated to the levels reported were addressed. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. No suitable data for the assessment were available. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for trimethoprim.

KW - Trimethoprim

KW - antimicrobial resistance

KW - sub-inhibitory concentration

KW - Feed Antimicrobial Resistance Selection Concentration (FARSC)

KW - growth promotion

KW - yield increase

KW - food-producing animals

U2 - 10.2903/j.efsa.2021.6865

DO - 10.2903/j.efsa.2021.6865

M3 - Journal article

C2 - 34729093

VL - 19

SP - 1

EP - 21

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 10

M1 - e06865

ER -