PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs

Research output: Contribution to journal › Journal article › Research › peer-review

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PigBiobank : a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs. / Zeng, Haonan; Zhang, Wenjing; Lin, Qing; Gao, Yahui; Teng, Jinyan; Xu, Zhiting; Cai, Xiaodian; Zhong, Zhanming; Wu, Jun; Liu, Yuqiang; Diao, Shuqi; Wei, Chen; Gong, Wentao; Pan, Xiangchun; Li, Zedong; Huang, Xiaoyu; Chen, Xifan; Du, Jinshi; Zhao, Fuping; Zhao, Yunxiang; Ballester, Maria; Crespo-Piazuelo, Daniel; Amills, Marcel; Clop, Alex; Karlskov-Mortensen, Peter; Fredholm, Merete; Li, Pinghua; Huang, Ruihua; Tang, Guoqing; Li, Mingzhou; Liu, Xiaohong; Chen, Yaosheng; Zhang, Qin; Li, Jiaqi; Yuan, Xiaolong; Ding, Xiangdong; Fang, Lingzhao; Zhang, Zhe; The PigGTEx Consortium.

In: Nucleic Acids Research, Vol. 52, No. D1, 2024, p. D980-D989.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zeng, H, Zhang, W, Lin, Q, Gao, Y, Teng, J, Xu, Z, Cai, X, Zhong, Z, Wu, J, Liu, Y, Diao, S, Wei, C, Gong, W, Pan, X, Li, Z, Huang, X, Chen, X, Du, J, Zhao, F, Zhao, Y, Ballester, M, Crespo-Piazuelo, D, Amills, M, Clop, A, Karlskov-Mortensen, P, Fredholm, M, Li, P, Huang, R, Tang, G, Li, M, Liu, X, Chen, Y, Zhang, Q, Li, J, Yuan, X, Ding, X, Fang, L, Zhang, Z & The PigGTEx Consortium 2024, 'PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs', Nucleic Acids Research, vol. 52, no. D1, pp. D980-D989. https://doi.org/10.1093/nar/gkad1080

APA

Zeng, H., Zhang, W., Lin, Q., Gao, Y., Teng, J., Xu, Z., Cai, X., Zhong, Z., Wu, J., Liu, Y., Diao, S., Wei, C., Gong, W., Pan, X., Li, Z., Huang, X., Chen, X., Du, J., Zhao, F., ... The PigGTEx Consortium (2024). PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs. Nucleic Acids Research, 52(D1), D980-D989. https://doi.org/10.1093/nar/gkad1080

Vancouver

Zeng H, Zhang W, Lin Q, Gao Y, Teng J, Xu Z et al. PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs. Nucleic Acids Research. 2024;52(D1):D980-D989. https://doi.org/10.1093/nar/gkad1080

Author

Zeng, Haonan ; Zhang, Wenjing ; Lin, Qing ; Gao, Yahui ; Teng, Jinyan ; Xu, Zhiting ; Cai, Xiaodian ; Zhong, Zhanming ; Wu, Jun ; Liu, Yuqiang ; Diao, Shuqi ; Wei, Chen ; Gong, Wentao ; Pan, Xiangchun ; Li, Zedong ; Huang, Xiaoyu ; Chen, Xifan ; Du, Jinshi ; Zhao, Fuping ; Zhao, Yunxiang ; Ballester, Maria ; Crespo-Piazuelo, Daniel ; Amills, Marcel ; Clop, Alex ; Karlskov-Mortensen, Peter ; Fredholm, Merete ; Li, Pinghua ; Huang, Ruihua ; Tang, Guoqing ; Li, Mingzhou ; Liu, Xiaohong ; Chen, Yaosheng ; Zhang, Qin ; Li, Jiaqi ; Yuan, Xiaolong ; Ding, Xiangdong ; Fang, Lingzhao ; Zhang, Zhe ; The PigGTEx Consortium. / PigBiobank : a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs. In: Nucleic Acids Research. 2024 ; Vol. 52, No. D1. pp. D980-D989.

Bibtex

@article{805f899b995b4e5c8a5839fd9c7766c6,
title = "PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs",
abstract = "To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http://pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species.",
author = "Haonan Zeng and Wenjing Zhang and Qing Lin and Yahui Gao and Jinyan Teng and Zhiting Xu and Xiaodian Cai and Zhanming Zhong and Jun Wu and Yuqiang Liu and Shuqi Diao and Chen Wei and Wentao Gong and Xiangchun Pan and Zedong Li and Xiaoyu Huang and Xifan Chen and Jinshi Du and Fuping Zhao and Yunxiang Zhao and Maria Ballester and Daniel Crespo-Piazuelo and Marcel Amills and Alex Clop and Peter Karlskov-Mortensen and Merete Fredholm and Pinghua Li and Ruihua Huang and Guoqing Tang and Mingzhou Li and Xiaohong Liu and Yaosheng Chen and Qin Zhang and Jiaqi Li and Xiaolong Yuan and Xiangdong Ding and Lingzhao Fang and Zhe Zhang and {The PigGTEx Consortium}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",
year = "2024",
doi = "10.1093/nar/gkad1080",
language = "English",
volume = "52",
pages = "D980--D989",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "D1",

}

RIS

TY - JOUR

T1 - PigBiobank

T2 - a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs

AU - Zeng, Haonan

AU - Zhang, Wenjing

AU - Lin, Qing

AU - Gao, Yahui

AU - Teng, Jinyan

AU - Xu, Zhiting

AU - Cai, Xiaodian

AU - Zhong, Zhanming

AU - Wu, Jun

AU - Liu, Yuqiang

AU - Diao, Shuqi

AU - Wei, Chen

AU - Gong, Wentao

AU - Pan, Xiangchun

AU - Li, Zedong

AU - Huang, Xiaoyu

AU - Chen, Xifan

AU - Du, Jinshi

AU - Zhao, Fuping

AU - Zhao, Yunxiang

AU - Ballester, Maria

AU - Crespo-Piazuelo, Daniel

AU - Amills, Marcel

AU - Clop, Alex

AU - Karlskov-Mortensen, Peter

AU - Fredholm, Merete

AU - Li, Pinghua

AU - Huang, Ruihua

AU - Tang, Guoqing

AU - Li, Mingzhou

AU - Liu, Xiaohong

AU - Chen, Yaosheng

AU - Zhang, Qin

AU - Li, Jiaqi

AU - Yuan, Xiaolong

AU - Ding, Xiangdong

AU - Fang, Lingzhao

AU - Zhang, Zhe

AU - The PigGTEx Consortium

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024

Y1 - 2024

N2 - To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http://pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species.

AB - To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http://pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species.

U2 - 10.1093/nar/gkad1080

DO - 10.1093/nar/gkad1080

M3 - Journal article

C2 - 37956339

AN - SCOPUS:85181760510

VL - 52

SP - D980-D989

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -

ID: 385698687