Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism

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Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism. / Feng, Yayan; Liu, Xiaolei; Liu, Yuqi; Tang, Bin; Bai, Xue; Li, Chen; Wang, Xuelin; Deng, Yiqun; Gao, Fei; Liu, Mingyuan.

In: Frontiers in Cell and Developmental Biology, Vol. 9, 681839, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Feng, Y, Liu, X, Liu, Y, Tang, B, Bai, X, Li, C, Wang, X, Deng, Y, Gao, F & Liu, M 2021, 'Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism', Frontiers in Cell and Developmental Biology, vol. 9, 681839. https://doi.org/10.3389/fcell.2021.681839

APA

Feng, Y., Liu, X., Liu, Y., Tang, B., Bai, X., Li, C., Wang, X., Deng, Y., Gao, F., & Liu, M. (2021). Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism. Frontiers in Cell and Developmental Biology, 9, [681839]. https://doi.org/10.3389/fcell.2021.681839

Vancouver

Feng Y, Liu X, Liu Y, Tang B, Bai X, Li C et al. Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism. Frontiers in Cell and Developmental Biology. 2021;9. 681839. https://doi.org/10.3389/fcell.2021.681839

Author

Feng, Yayan ; Liu, Xiaolei ; Liu, Yuqi ; Tang, Bin ; Bai, Xue ; Li, Chen ; Wang, Xuelin ; Deng, Yiqun ; Gao, Fei ; Liu, Mingyuan. / Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism. In: Frontiers in Cell and Developmental Biology. 2021 ; Vol. 9.

Bibtex

@article{6b6df7bb39cf43eca136f74fa3cba804,
title = "Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism",
abstract = "Comparative epigenomics provides new insights on evolutionary biology in relation with complex interactions between species and their environments. In the present study, we focus on deciphering the conservation and divergence of DNA methylomes during Trichinella evolution. Whole-genome bisulfite sequencing and RNA-seq were performed on the two clades of Trichinella species, in addition to whole-genome sequencing. We demonstrate that methylation patterns of sing-copy orthologous genes (SCOs) of the 12 Trichinella species are host-related and can mirror known phylogenetic relationships. Among these SCOs, we identify a panel of genes exhibiting hyper-/hypo-methylated features in gene-bodies or respective promoters that play pivotal roles in transcriptome regulation. These hyper-/hypo-methylated SCOs are also of functional significance across developmental stages, as they are highly enriched species-specific and stage-specific expressed genes both in Ad and ML stages. We further identify a set of parasitism-related functional genes that exhibit host-related differential methylation and expression among those SCOs, including p53-like transcription factor and Cdc37 that are of functional significance for elucidating differential parasitology between the two clades of Trichinella. This comparative epigenome study can help to decipher the environmental effects on differential adaptation and parasitism of the genus Trichinella.",
keywords = "comparative epigenomics, differential parasitism, host-related methylomes, hyper-/hypo-methylated SCOs, Trichinella",
author = "Yayan Feng and Xiaolei Liu and Yuqi Liu and Bin Tang and Xue Bai and Chen Li and Xuelin Wang and Yiqun Deng and Fei Gao and Mingyuan Liu",
note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Feng, Liu, Liu, Tang, Bai, Li, Wang, Deng, Gao and Liu.",
year = "2021",
doi = "10.3389/fcell.2021.681839",
language = "English",
volume = "9",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism

AU - Feng, Yayan

AU - Liu, Xiaolei

AU - Liu, Yuqi

AU - Tang, Bin

AU - Bai, Xue

AU - Li, Chen

AU - Wang, Xuelin

AU - Deng, Yiqun

AU - Gao, Fei

AU - Liu, Mingyuan

N1 - Publisher Copyright: © Copyright © 2021 Feng, Liu, Liu, Tang, Bai, Li, Wang, Deng, Gao and Liu.

PY - 2021

Y1 - 2021

N2 - Comparative epigenomics provides new insights on evolutionary biology in relation with complex interactions between species and their environments. In the present study, we focus on deciphering the conservation and divergence of DNA methylomes during Trichinella evolution. Whole-genome bisulfite sequencing and RNA-seq were performed on the two clades of Trichinella species, in addition to whole-genome sequencing. We demonstrate that methylation patterns of sing-copy orthologous genes (SCOs) of the 12 Trichinella species are host-related and can mirror known phylogenetic relationships. Among these SCOs, we identify a panel of genes exhibiting hyper-/hypo-methylated features in gene-bodies or respective promoters that play pivotal roles in transcriptome regulation. These hyper-/hypo-methylated SCOs are also of functional significance across developmental stages, as they are highly enriched species-specific and stage-specific expressed genes both in Ad and ML stages. We further identify a set of parasitism-related functional genes that exhibit host-related differential methylation and expression among those SCOs, including p53-like transcription factor and Cdc37 that are of functional significance for elucidating differential parasitology between the two clades of Trichinella. This comparative epigenome study can help to decipher the environmental effects on differential adaptation and parasitism of the genus Trichinella.

AB - Comparative epigenomics provides new insights on evolutionary biology in relation with complex interactions between species and their environments. In the present study, we focus on deciphering the conservation and divergence of DNA methylomes during Trichinella evolution. Whole-genome bisulfite sequencing and RNA-seq were performed on the two clades of Trichinella species, in addition to whole-genome sequencing. We demonstrate that methylation patterns of sing-copy orthologous genes (SCOs) of the 12 Trichinella species are host-related and can mirror known phylogenetic relationships. Among these SCOs, we identify a panel of genes exhibiting hyper-/hypo-methylated features in gene-bodies or respective promoters that play pivotal roles in transcriptome regulation. These hyper-/hypo-methylated SCOs are also of functional significance across developmental stages, as they are highly enriched species-specific and stage-specific expressed genes both in Ad and ML stages. We further identify a set of parasitism-related functional genes that exhibit host-related differential methylation and expression among those SCOs, including p53-like transcription factor and Cdc37 that are of functional significance for elucidating differential parasitology between the two clades of Trichinella. This comparative epigenome study can help to decipher the environmental effects on differential adaptation and parasitism of the genus Trichinella.

KW - comparative epigenomics

KW - differential parasitism

KW - host-related methylomes

KW - hyper-/hypo-methylated SCOs

KW - Trichinella

U2 - 10.3389/fcell.2021.681839

DO - 10.3389/fcell.2021.681839

M3 - Journal article

C2 - 34179010

AN - SCOPUS:85108872014

VL - 9

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 681839

ER -

ID: 273639238