Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation. / Mortensen, Janni Støvring; Bohr, Søren S.R.; Krog, Lasse Skjoldborg; Bøtker, Johan Peter; Kapousidou, Vaya; Saaby, Lasse; Hatzakis, Nikos S.; Mørck Nielsen, Hanne; Nguyen, Duc Ninh; Rønholt, Stine.
In: Scientific Reports, Vol. 14, No. 1, 7665, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
AU - Mortensen, Janni Støvring
AU - Bohr, Søren S.R.
AU - Krog, Lasse Skjoldborg
AU - Bøtker, Johan Peter
AU - Kapousidou, Vaya
AU - Saaby, Lasse
AU - Hatzakis, Nikos S.
AU - Mørck Nielsen, Hanne
AU - Nguyen, Duc Ninh
AU - Rønholt, Stine
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - The integrity of the intestinal mucus barrier is crucial for human health, as it serves as the body's first line of defense against pathogens. However, postnatal development of the mucus barrier and interactions between maturity and its ability to adapt to external challenges in neonatal infants remain unclear. In this study, we unveil a distinct developmental trajectory of the mucus barrier in preterm piglets, leading to enhanced mucus microstructure and reduced mucus diffusivity compared to term piglets. Notably, we found that necrotizing enterocolitis (NEC) is associated with increased mucus diffusivity of our large pathogen model compound, establishing a direct link between the NEC condition and the mucus barrier. Furthermore, we observed that addition of sodium decanoate had varying effects on mucus diffusivity depending on maturity and health state of the piglets. These findings demonstrate that regulatory mechanisms governing the neonatal mucosal barrier are highly complex and are influenced by age, maturity, and health conditions. Therefore, our results highlight the need for specific therapeutic strategies tailored to each neonatal period to ensure optimal gut health.
AB - The integrity of the intestinal mucus barrier is crucial for human health, as it serves as the body's first line of defense against pathogens. However, postnatal development of the mucus barrier and interactions between maturity and its ability to adapt to external challenges in neonatal infants remain unclear. In this study, we unveil a distinct developmental trajectory of the mucus barrier in preterm piglets, leading to enhanced mucus microstructure and reduced mucus diffusivity compared to term piglets. Notably, we found that necrotizing enterocolitis (NEC) is associated with increased mucus diffusivity of our large pathogen model compound, establishing a direct link between the NEC condition and the mucus barrier. Furthermore, we observed that addition of sodium decanoate had varying effects on mucus diffusivity depending on maturity and health state of the piglets. These findings demonstrate that regulatory mechanisms governing the neonatal mucosal barrier are highly complex and are influenced by age, maturity, and health conditions. Therefore, our results highlight the need for specific therapeutic strategies tailored to each neonatal period to ensure optimal gut health.
KW - Intestinal barrier
KW - Mucus diffusivity
KW - Necrotizing enterocolitis
KW - Neonatal
KW - Perinatal asphyxia
KW - Sodium caprate supplement
U2 - 10.1038/s41598-024-58356-5
DO - 10.1038/s41598-024-58356-5
M3 - Journal article
C2 - 38561398
AN - SCOPUS:85189068061
VL - 14
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 7665
ER -
ID: 387933965