Dorte Frees
Associate Professor
- 2024
- Published
Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool
Olsen, John Elmerdahl, Frees, Dorte, Kyvsgaard, N. C. & Barco, L., 2024, In: Letters in Applied Microbiology. 77, 2, 9 p., ovae015.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division
Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, Dorte, 2024, In: Molecular Microbiology. 121, 1, p. 98-115Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology
Xu, Lijuan, Henriksen, C., Mebus, Viktor Hundtofte, Guérillot, R., Petersen, A., Jacques, N., Jiang, J. H., Derks, R. J. E., Sánchez-López, E., Giera, M., Leeten, K., Stinear, T. P., Oury, C., Howden, B. P., Peleg, A. Y. & Frees, Dorte, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor
Mellergaard, M., Skovbakke, S. L., Jepsen, S. D., Panagiotopoulou, N., Hansen, A. B. R., Tian, W., Lund, A., Høgh, R. I., Møller, S. H., Guérillot, R., Hayes, A. S., Erikstrup, L. T., Andresen, L., Peleg, A. Y., Larsen, A. R., Stinear, T. P., Handberg, A., Erikstrup, C., Howden, B. P., Goletz, S. & 2 others, , 2023, In: mBio. 14, 5, 21 p., e01349-23.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study
Nielsen, O. L., Mellergaard, M., Frees, Dorte, Larsen, M. N., Skov, Søren, Olsen, Lisbeth Høier & Reimann, Maria Josefine, 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Finding New Fundamental Pieces for the Bacterial Cell Division Puzzle
Frees, Dorte & Ingmer, Hanne, 2022, In: mBio. 13, 4, e0073722.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid in vivo development of resistance to daptomycin in vancomycin-resistant Enterococcus faecium due to genomic alterations
Mollerup, S., Elmeskov, C., Pinholt, M., Sejersen, T. S., Pedersen, M. S., Worning, P., Frees, Dorte & Westh, Henrik T., 2022, In: FEMS Microbiology Letters. 369, 1, 6 p., 063.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA
Bæk, K. T., Jensen, C., Farha, M. A., Nielsen, T. K., Paknejadi, E., Mebus, Viktor Hundtofte, Vestergaard, M., Brown, E. D. & Frees, Dorte, 2021, In: Frontiers in Molecular Biosciences. 8, 691569.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cefoxitin treatment of MRSA leads to a shift in the IL-12/IL-23 production pattern in dendritic cells by a mechanism involving changes in the MAPK signaling
Eld, H. M. S., Nielsen, E. M., Johnsen, Peter Riber, Marengo, M., Kamper, I. W., Frederiksen, L., Bonomi, F., Frees, Dorte, Iametti, S. & Frøkiær, Hanne, 2021, In: Molecular Immunology. 134, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Staphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase
Alqarzaee, A. A., Chaudhari, S. S., Islam, M. M., Kumar, V., Zimmerman, M. C., Saha, R., Bayles, K. W., Frees, Dorte & Thomas, V. C., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2109671118.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes
Mellergaard, M., Høgh, R. I., Feilberg, Astrid Lund, Aldana, Blanca, Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, Stine Dam, Hansen, Camilla Hartmann Friis, Andresen, Lars, Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, Helle S., Frees, Dorte & Skov, Søren, 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec
Schelin, J., Cohn, M. T., Frisk, B. & Frees, Dorte, 2020, In: Toxins. 12, 9, 553.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus
Jensen, C., Li, H., Vestergaard, M., Dalsgaard, Anders, Frees, Dorte & Leisner, Jørgen, 2020, In: Frontiers in Microbiology. 11, 8 p., 1007.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SosA in Staphylococci: an addition to the paradigm of membrane-localized, SOS-induced cell division inhibition in bacteria
Bojer, Martin Saxtorph, Frees, Dorte & Ingmer, Hanne, 2020, In: Current Genetics. 66, p. 495-499Research output: Contribution to journal › Review › Research › peer-review
- Published
The sle1 cell wall amidase is essential for β-lactam resistance in community-acquired methicillin-resistant staphylococcus aureus USA300
Thalsø-Madsen, I., Torrubia, F. R., Xu, Lijuan, Petersen, A., Jensen, C. & Frees, Dorte, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 1, 15 p., e01931-19.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, Dorte, 2019, In: Scientific Reports. 9, 11 p., 16456.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibiotic Resistance and the MRSA Problem
Vestergaard, M., Frees, Dorte & Ingmer, Hanne, 2019, In: Microbiology Spectrum. 7, 2, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fødevaresikkerhed i udvikling
Ingmer, Hanne, Larsen, M. H., Leisner, Jørgen, Frees, Dorte, Brøndsted, Lone & Dalsgaard, Anders, 2019, In: Dansk Veterinaertidsskrift. 2019, 7, p. 10-13Research output: Contribution to journal › Journal article › Communication
- Published
SosA inhibits cell division in Staphylococcus aureus in response to DNA damage
Bojer, Martin Saxtorph, Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, Dorte, Veening, J. W., Foster, S. J. & Ingmer, Hanne, 2019, In: Molecular Microbiology. 112, 4, p. 1116-1130Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis
Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, Lijuan, Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, Dorte, 2019, In: PLOS Pathogens. 15, 9, 27 p., e1008044.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
Baldry, M., Nakamura, Y., Nakagawa, S., Frees, Dorte, Matsue, H., Nunez, G. & Ingmer, Hanne, 2018, In: Journal of Infectious Diseases. 218, 6, p. 1009-1013Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A porcine subcutaneous Staphylococcus aureus abscess model - a pilot study
Nielsen, O. L., Larsen, M. N., Frees, Dorte, Pedersen, M. M., Skov, Søren & Olsen, Lisbeth Høier, 2017.Research output: Contribution to conference › Conference abstract for conference › Communication
- Published
The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, Dorte, 2017, In: Scientific Reports. 7, 14 p., 11739.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus
Baldry, M., Nielsen, A., Bojer, Martin Saxtorph, Zhao, Y., Friberg, C., Ifrah, D., Heede, N. G., Larsen, T. O., Frøkiær, Hanne, Frees, Dorte, Zhang, L., Dai, H. & Ingmer, Hanne, 22 Dec 2016, In: PLOS ONE. 11, 12, 16 p., e0168305.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus
Villanueva, M., Jousselin, A., Baek, K. T., Prados, J., Andrey, D. O., Renzoni, A., Ingmer, Hanne, Frees, Dorte & Kelley, W. L., 1 Oct 2016, In: Journal of Bacteriology. 198, 19, p. 2719-2731 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis
Breüner, A., Frees, Dorte, Varmanen, P., Boguta, A. M., Hammer, K., Martinussen, J. & Kilstrup, M., Oct 2016, In: Microbiology. 162, 10, p. 1829-1839 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stress Responses in Staphylococcus aureus
Frees, Dorte & Ingmer, Hanne, Oct 2016, Staphylococcus: Genetics and Physiology. Somerville, G. A. (ed.). Caister Academic Press, p. 221-248Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri
Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte, Dalsgaard, I. & Jørgensen, Louise von Gersdorff, 12 Jul 2016, In: P L o S One. 11, 7, e0158968.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
Larsen, J., Clasen, J., Hansen, J. E., Paulander, W., Petersen, A., Larsen, A. R. & Frees, Dorte, Jul 2016, In: Antimicrobial Agents and Chemotherapy. 60, 7, p. 4401-4403Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antigen uptake in zebrafish (Danio rerio) at different life stages
Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Jørgensen, Louise von Gersdorff, 2016.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone
Baek, K. T., Bowman, L., Millership, C., Sogaard, M. D., Kaever, V., Siljamaki, P., Savijoki, K., Varmanen, P., Nyman, T. A., Grundling, A. & Frees, Dorte, 2016, In: mBio (Print). 7, 4, 11 p., 01228.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene
Bæk, K. T., Thøgersen, L., Mogensen, R. G., Pedersen, M. M., Thomsen, Line Elnif, Petersen, A., Skov, Søren, Cameron, D. R., Peleg, A. Y. & Frees, Dorte, Nov 2015, In: Antimicrobial Agents and Chemotherapy. 59, 11, p. 6983-6991 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus
Farrand, A. J., Friedman, D. B., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., Apr 2015, In: Pathogens and Disease. 73, 3, 6 p., ftv004.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
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- 2014
- Published
Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus
Frees, Dorte, Gerth, U. & Ingmer, Hanne, 2014, In: International Journal of Medical Microbiology. 304, 2, p. 142-149 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils
Nielsen, A., Månsson, M., Bojer, Martin Saxtorph, Gram, L., Larsen, T. O., Novick, R. P., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, 2014, In: P L o S One. 9, 1, p. e84992 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
β-lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease
Bæk, K. T., Gründling, A., Mogensen, R. G., Thøgersen, L., Petersen, A., Paulander, W. E. A. & Frees, Dorte, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 8, p. 4593-4603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Bacterial proteases and virulence
Frees, Dorte, Brøndsted, Lone & Ingmer, Hanne, 2013, Regulated proteolysis in microorganisms. Dougan, D. A. (ed.). Springer, p. 161-192 32 p. (Subcellular biochemistry, Vol. 66).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, K. T., Frees, Dorte, Renzoni, A., Barras, C., Rodriguez, N., Manzano, C. & Kelley, W. L., 2013, In: P L o S One. 8, 9, 16 p., e77122.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system
Farrand, A. J., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., 2013, In: Journal of Bacteriology. 195, 22, p. 5041-5050 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice
Harslund, J. L. F., Frees, Dorte, Leifsson, Páll S., Offenberg, H. K., Rømer, M. U. K., Brünner, N. & Olsen, John Elmerdahl, 2013, In: Pathogens and Disease. 68, 3, p. 96-104 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Therapy of haematogenous osteomyelitis: a comparative study in a porcine model and Angolan children
Jensen, Louise Kruse, Koch, J., Kirketerp-Møller, K., Wamsler, O. J., Nielsen, O. L., Leifsson, Páll S., Frees, Dorte, Aalbæk, Bent & Jensen, Henrik Elvang, 2013, In: In Vivo. 27, 3, p. 305-312 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus
Feng, J., Michalik, S., Varming, A. N., Andersen, J. H., Albrecht, D., Jelsbak, L., Krieger, S., Ohlsen, K., Hecker, M., Gerth, U., Ingmer, Hanne & Frees, Dorte, 2013, In: Journal of Proteome Research. 12, 2, p. 547-558 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Solonamide B Inhibits Quorum Sensing and reduces Staphylococcus aureus mediated killing of Human Neutrophils
Nielsen, A., Månsson, M., Gram, L., Larsen, T. O., Phipps, R. K., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, Aug 2012.Research output: Contribution to conference › Poster › Research
- Published
A porcine model of heamatogenous osteomyelitis: pathogenesis and pathology
Jensen, Louise Kruse, Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Buelund, Lene Elisabeth, Svalastoga, Eiliv Lars & Jensen, Henrik Elvang, 2012. 1 p.Research output: Contribution to conference › Poster › Research
- Published
Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus
Paulander, W. E. A., Varming, A. N., Bæk, K. T., Haaber, J. K., Frees, Dorte & Ingmer, Hanne, 2012, In: mBio. 3, 6, p. e00459-12 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis
Jensen, Louise Kruse, Iburg, T. M., Nielsen, O. L., Leifsson, Páll S., Dahl-Pedersen, Kirstin, Koch, J., Frees, Dorte, Aalbæk, Bent, Heegaard, P. M. H. & Jensen, Henrik Elvang, 2012, In: Prostaglandins & Other Lipid Mediators. 97, 3-4, p. 103-108 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564
Frees, Dorte, Andersen, J. H., Hemmingsen, L., Koskenniemi, K., Bæk, K. T., Muhammed, Musemma Kedir, Gudeta, D. D., Nyman, T. A., Sukura, A., Varmanen, P. & Savijoki, K., 2012, In: Journal of Proteome Research. 11, 1, p. 95-108 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4233088
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Planktonic aggregates of Staphylococcus aureus protect against common antibiotics
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The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by rot dependent and independent pathways
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The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
Research output: Contribution to journal › Journal article › Research › peer-review
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