Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi
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Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi. / Gless, Bengt Herbert; Peng, Pai; Pedersen, Katja D.; Gotfredsen, Charlotte H.; Ingmer, Hanne; Olsen, Christian Adam.
In: Organic Letters, Vol. 19, No. 19, 2017, p. 5276–5279.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi
AU - Gless, Bengt Herbert
AU - Peng, Pai
AU - Pedersen, Katja D.
AU - Gotfredsen, Charlotte H.
AU - Ingmer, Hanne
AU - Olsen, Christian Adam
PY - 2017
Y1 - 2017
N2 - Herein, an effective protocol for solid-phase synthesis of peptide thiolactones by concomitant ring closure and cleavage from the solid support is reported. The strategy was applied for mapping the importance of the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this natural compound. This furnished some of the most potent inhibitors of accessory gene regulator (agr)-I in the human pathogen S. aureus reported to date.
AB - Herein, an effective protocol for solid-phase synthesis of peptide thiolactones by concomitant ring closure and cleavage from the solid support is reported. The strategy was applied for mapping the importance of the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this natural compound. This furnished some of the most potent inhibitors of accessory gene regulator (agr)-I in the human pathogen S. aureus reported to date.
U2 - 10.1021/acs.orglett.7b02550
DO - 10.1021/acs.orglett.7b02550
M3 - Letter
C2 - 28952740
VL - 19
SP - 5276
EP - 5279
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 19
ER -
ID: 184203354