Enzootic and zoonotic virus research: The Lars Erik Larsen group

The overarching goal of our work is to contribute to increased animal welfare and food safety in the Danish animal production. The core research areas are enzootic viral diseases in pigs and other production animals and zoonotic viruses in pigs and birds.


The Enzootic and Zoonotic virus research group
Dyrlægevej 88, building 1-09
Frederiksberg Campus
1870 Frederiksberg C


























Kvisgaard LK, Larsen LE, Kristensen CS, Paboeuf F, Renson P, Bourry O. 2021Challenge of Naïve and Vaccinated Pigs with a Vaccine-Derived Recombinant Porcine Reproductive and Respiratory Syndrome Virus 1 Strain (Horsens Strain). Vaccines 9(5):417. https://doi.org/10.3390/vaccines9050417

Liang Y, Nissen JN, Krog JS, Breum SØ, Trebbien R, Larsen LE, Hjulsager CK. 2021Novel Clade Highly Pathogenic Avian Influenza A H5N8 and H5N5 Viruses in Denmark, 2020. Viruses 13(5):886.  https://doi.org/10.3390/v13050886

Jensen KJ, Tolstrup LK, Knobel DL, Aaby P, Jungersen G, Larsen LE, Kristensen CS, Benn CS. 2021. Non-specific effects of maternal and offspring rabies vaccination on mortality and antibiotic use in a Danish pig herd: A randomized trial. Vaccine S0264-410X(21)00399-6. https://doi.org/10.1016/j.vaccine.2021.03.083

Welner S, Ruggli N, Liniger M, Summerfield A, Larsen LE, Jungersen G. 2021. Reduced Virus Load in Lungs of Pigs Challenged with Porcine Reproductive and Respiratory Syndrome Virus after Vaccination with Virus Replicon Particles Encoding Conserved PRRSV Cytotoxic T-Cell Epitopes. Vaccines 9(3):208.; https://doi.org/10.3390/vaccines9030208

Ryt-Hansen, P.; Pedersen, A.G.; Larsen, I.; Kristensen, C.S.; Krog, J.S.; Wacheck, S.; Larsen, L.E. 2020. Substantial Antigenic Drift in the Hemagglutinin Protein of Swine Influenza A Viruses. Viruses 12, 248. ; https://doi.org/10.3390/v12020248 

Goecke NB, Kobberø M, Kusk TK, Hjulsager CK, Pedersen KS, Kristensen CS, Larsen LE. 2020Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing. Porcine Health Manag. 6:23. https://doi.org/10.1186/s40813-020-00161-3

C S KristensenM G ChristiansenK PedersenL E Larsen. 2020Production losses five months after outbreak with a recombinant of two PRRSV vaccine strains in 13 Danish sow herds. Porcine Health Manag. 6:26. ; https://doi.org/10.1186/s40813-020-00165-z























Avian influenza: Diagnosis and molecular biological characterization
The project will increase our basic knowledge of the epidemiology of AIV in Danish conditions and will lead to the development of more refined diagnostic tests.

Veterinary contingency program. 2019-21. 2.5 million DKK.

Control of viral infections relevant to piglet mortality

The project aims to develop and implement knowledge-based counseling tools to control the most important virus infections in Danish pig production, specifically aimed at reducing piglet mortality.

Funding: Svineafgiftsfonden; 1,825,000 DKK. Period: 2022.

FluZooMark: Viral and Host Factors of Zoonotic and Pandemic Influenza A Viruses
Researchers in virology and immunology in animals and humans will work together to characterize human and animal influenza viruses to find out why some influenza viruses can transmit from swine to humans. The project is expected to generate groundbreaking new tools for preventing future influenza pandemics in humans and provide knowledge that can be used in the future to design improved vaccines for humans and animals.

Funding: Novo Nordisk Foundation Challenge program 2019. 60 mill. DKK.

PIGIE - Understanding the dynamics and evolution of swine influenza viruses in Europe

Researchers from Denmark, France, Germany, Italy, Spain and United Kingdom will perform a longitudinal that will provide essential knowledge for improved intervention and sustainable pig production, and will also be important for further development of more accurate diagnostic tools and relevant vaccines.

Funding: ICRAD; 1,353,000 DKK (1,375,00 EURO in total)

Swine influenza viruses in Denmark: Prevalence and genetic and antigenic characterization

The overall purpose of the project is to investigate which influenza subtypes and variants that are circulating among Danish pigs and to identify disease causes in the pig population with a view to securing the strategic goal: to reduce antibiotic consumption in Danish pig herds.

Funding: CEVA Animal Health and the Danish Veterinary and Food Administration. 2021. DKK 1.054,000.









































Research Group leader

Research Group Leader

Lars Erik Larsen


Phone +45 3533 2329

Group/project members

Internal researchers

Name Title Phone E-mail
George, Sophie Joanna PhD Fellow   E-mail
Goecke, Nicole Bakkegård Postdoc +4535327222 E-mail
Grønnegaard, Nina Dam Laboratory Technician +4535328312 E-mail
Kristensen, Charlotte PhD Student   E-mail
Kvisgaard, Lise Kirstine Academic Research Staff +4535321617 E-mail
Larsen, Lars Erik Professor +4535332329 E-mail
Liang, Yuan PhD Fellow +4535337865 E-mail
Martiny, Karen Anna Handberg Student +4535322266 E-mail
Ryt-Hansen, Pia Postdoc +4535334530 E-mail
Tran, Hue Thi Thanh Laboratory Technician +4535322549 E-mail
Welner, Simon Postdoc +4535320258 E-mail