Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree
Forlagets udgivne version, 0,99 MB, PDF-dokument
The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.
Originalsprog | Engelsk |
---|---|
Artikelnummer | e00234 |
Tidsskrift | Endocrinology, Diabetes and Metabolism |
Vol/bind | 4 |
Udgave nummer | 3 |
ISSN | 2398-9238 |
DOI | |
Status | Udgivet - 2021 |
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 259101357