Addressing misclassification bias in vaccine effectiveness studies with an application to Covid-19
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Safe and effective vaccines are crucial for the control of Covid-19 and to protect individuals at higher risk of severe disease. The test-negative design is a popular option for evaluating the effectiveness of Covid-19 vaccines. However, the findings could be biased by several factors, including imperfect sensitivity and/or specificity of the test used for diagnosing the SARS-Cov-2 infection. We propose a simple Bayesian modeling approach for estimating vaccine effectiveness that is robust even when the diagnostic test is imperfect. We use simulation studies to demonstrate the robustness of our method to misclassification bias and illustrate the utility of our approach using real-world examples.
Originalsprog | Engelsk |
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Artikelnummer | 55 |
Tidsskrift | BMC Medical Research Methodology |
Vol/bind | 23 |
ISSN | 1471-2288 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Publisher Copyright:
© 2023, The Author(s).
ID: 339002946