Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains
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Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains. / Manger, Paul R.; Patzke, Nina; Spocter, Muhammad A.; Bhagwandin, Adhil; Karlsson, Karl; Bertelsen, Mads F.; Alagaili, Abdulaziz N.; Bennett, Nigel C.; Mohammed, Osama B.; Herculano-Houzel, Suzana; Hof, Patrick R.; Fuxe, Kjell.
I: Scientific Reports, Bind 11, 5486, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains
AU - Manger, Paul R.
AU - Patzke, Nina
AU - Spocter, Muhammad A.
AU - Bhagwandin, Adhil
AU - Karlsson, Karl
AU - Bertelsen, Mads F.
AU - Alagaili, Abdulaziz N.
AU - Bennett, Nigel C.
AU - Mohammed, Osama B.
AU - Herculano-Houzel, Suzana
AU - Hof, Patrick R.
AU - Fuxe, Kjell
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16 brains from 14 cetartiodactyl species, with immunohistochemical techniques, for evidence of non-shivering thermogenesis. We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (from 3 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inner membrane proteins that dissipate the proton gradient to generate heat) in cortical neurons, immunolocalization of UCP4 within a substantial proportion of glia throughout the brain, and an increased density of noradrenergic axonal boutons (noradrenaline functioning to control concentrations of and activate UCPs). Thus, cetacean brains studied possess multiple characteristics indicative of intensified thermogenetic functionality that can be related to their current and historical obligatory aquatic niche. These findings necessitate reassessment of our concepts regarding the reasons for large brain evolution and associated functional capacities in cetaceans.
AB - To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16 brains from 14 cetartiodactyl species, with immunohistochemical techniques, for evidence of non-shivering thermogenesis. We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (from 3 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inner membrane proteins that dissipate the proton gradient to generate heat) in cortical neurons, immunolocalization of UCP4 within a substantial proportion of glia throughout the brain, and an increased density of noradrenergic axonal boutons (noradrenaline functioning to control concentrations of and activate UCPs). Thus, cetacean brains studied possess multiple characteristics indicative of intensified thermogenetic functionality that can be related to their current and historical obligatory aquatic niche. These findings necessitate reassessment of our concepts regarding the reasons for large brain evolution and associated functional capacities in cetaceans.
U2 - 10.1038/s41598-021-84762-0
DO - 10.1038/s41598-021-84762-0
M3 - Journal article
C2 - 33750832
AN - SCOPUS:85102243728
VL - 11
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 5486
ER -
ID: 282940176