Micro RNAs are associated with several diabetes complications especially the diabetic foot ulcers development. MiRNAs regulate the expression of genes which can lead to delay in wound healing in diabetic foot ulcer and ultimately amputation, a life threatening risk. To trace the role of miRNAs which are associated in the development of diabetic foot ulcer and ultimately amputation? We performed a RT-PCR approach. MiRNA-146a, miRNA-21, and miRNA-210 were analyzed with RT-PCR expression analysis difference between Diabetic foot ulcer and controls. MiRNA-210 over-expressed in diabetic foot ulcers while miRNA-146a, and miRNA-21, down regulated as compare to diabetes patients. Screened miRNAs can be used for further investigation therefore their role will be clear to save foot ulcer individuals from amputation.