Dorte Frees
Associate Professor
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Staphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase
Alqarzaee, A. A., Chaudhari, S. S., Islam, M. M., Kumar, V., Zimmerman, M. C., Saha, R., Bayles, K. W., Frees, Dorte & Thomas, V. C., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2109671118.Research output: Contribution to journal › Journal article › Research › peer-review
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The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone
Baek, K. T., Bowman, L., Millership, C., Sogaard, M. D., Kaever, V., Siljamaki, P., Savijoki, K., Varmanen, P., Nyman, T. A., Grundling, A. & Frees, Dorte, 2016, In: mBio (Print). 7, 4, 11 p., 01228.Research output: Contribution to journal › Journal article › Research › peer-review
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Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus
Baldry, M., Nielsen, A., Bojer, Martin Saxtorph, Zhao, Y., Friberg, C., Ifrah, D., Heede, N. G., Larsen, T. O., Frøkiær, Hanne, Frees, Dorte, Zhang, L., Dai, H. & Ingmer, Hanne, 22 Dec 2016, In: PLOS ONE. 11, 12, 16 p., e0168305.Research output: Contribution to journal › Journal article › Research › peer-review
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Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
Baldry, M., Nakamura, Y., Nakagawa, S., Frees, Dorte, Matsue, H., Nunez, G. & Ingmer, Hanne, 2018, In: Journal of Infectious Diseases. 218, 6, p. 1009-1013Research output: Contribution to journal › Journal article › Research › peer-review
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SosA in Staphylococci: an addition to the paradigm of membrane-localized, SOS-induced cell division inhibition in bacteria
Bojer, Martin Saxtorph, Frees, Dorte & Ingmer, Hanne, 2020, In: Current Genetics. 66, p. 495-499Research output: Contribution to journal › Review › Research › peer-review
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SosA inhibits cell division in Staphylococcus aureus in response to DNA damage
Bojer, Martin Saxtorph, Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, Dorte, Veening, J. W., Foster, S. J. & Ingmer, Hanne, 2019, In: Molecular Microbiology. 112, 4, p. 1116-1130Research output: Contribution to journal › Journal article › Research › peer-review
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Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis
Breüner, A., Frees, Dorte, Varmanen, P., Boguta, A. M., Hammer, K., Martinussen, J. & Kilstrup, M., Oct 2016, In: Microbiology. 162, 10, p. 1829-1839 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA
Bæk, K. T., Jensen, C., Farha, M. A., Nielsen, T. K., Paknejadi, E., Mebus, Viktor Hundtofte, Vestergaard, M., Brown, E. D. & Frees, Dorte, 2021, In: Frontiers in Molecular Biosciences. 8, 691569.Research output: Contribution to journal › Journal article › Research › peer-review
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Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene
Bæk, K. T., Thøgersen, L., Mogensen, R. G., Pedersen, M. M., Thomsen, Line Elnif, Petersen, A., Skov, Søren, Cameron, D. R., Peleg, A. Y. & Frees, Dorte, Nov 2015, In: Antimicrobial Agents and Chemotherapy. 59, 11, p. 6983-6991 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, K. T., Frees, Dorte, Renzoni, A., Barras, C., Rodriguez, N., Manzano, C. & Kelley, W. L., 2013, In: P L o S One. 8, 9, 16 p., e77122.Research output: Contribution to journal › Journal article › Research › peer-review
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β-lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease
Bæk, K. T., Gründling, A., Mogensen, R. G., Thøgersen, L., Petersen, A., Paulander, W. E. A. & Frees, Dorte, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 8, p. 4593-4603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clp-dependent proteolysis of the LexA N-terminal domain in Staphylococcus aureus
Cohn, M. T., Kjelgaard, P. M., Frees, Dorte, Penadés, J. R. & Ingmer, Hanne, 2011, In: Microbiology. 157, 3, p. 677-684 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cefoxitin treatment of MRSA leads to a shift in the IL-12/IL-23 production pattern in dendritic cells by a mechanism involving changes in the MAPK signaling
Eld, H. M. S., Nielsen, E. M., Johnsen, Peter Riber, Marengo, M., Kamper, I. W., Frederiksen, L., Bonomi, F., Frees, Dorte, Iametti, S. & Frøkiær, Hanne, 2021, In: Molecular Immunology. 134, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus
Engman, J., Rogstam, A. H., Frees, Dorte, Ingmer, Hanne & Wachenfeldt, C. V., 2012, In: Journal of Bacteriology. 194, 5, p. 1186-1194 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus
Farrand, A. J., Friedman, D. B., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., Apr 2015, In: Pathogens and Disease. 73, 3, 6 p., ftv004.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system
Farrand, A. J., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., 2013, In: Journal of Bacteriology. 195, 22, p. 5041-5050 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus
Feng, J., Michalik, S., Varming, A. N., Andersen, J. H., Albrecht, D., Jelsbak, L., Krieger, S., Ohlsen, K., Hecker, M., Gerth, U., Ingmer, Hanne & Frees, Dorte, 2013, In: Journal of Proteome Research. 12, 2, p. 547-558 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins and concomitantly increases stress tolerance in Lactococcus lactis
Frees, Dorte, Varmanen, P. & Ingmer, Hanne, 2001, In: Molecular Microbiology. 41, 1, p. 93-103 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus
Frees, Dorte, Chastanet, A., Quzi, S., Sørensen, K., Hill, P., Msadek, T. & Ingmer, Hanne, 2004, In: Molecular Microbiology. 54, 5, p. 1445-1462 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stress toelrance mechanisms influencing virulence and survival of food borne pathogens
Frees, Dorte, Varmanen, P. ;., SavijokiK.;, Andersen, M. T., Brønsted, L. & Ingmer, Hanne, 2003. 1 p.Research output: Contribution to conference › Paper › Research
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Alternative roles of CIpX and CIpP in Staphylococus aureus stress toelrance and virulence.
Frees, Dorte, Saara, N. A. Q., Philip, J. H. & Ingmer, Hanne, 2003, In: Molecular Microbiology. (2003) 48 (6), p. 1565 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ClpP participaytes in the degradation of misfolded protein in Lactococcuss lactis
Frees, Dorte & Ingmer, Hanne, 1999, In: Molecular Microbiology. 31, 1, p. 79 - 87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stress Responses in Staphylococcus aureus
Frees, Dorte & Ingmer, Hanne, Oct 2016, Staphylococcus: Genetics and Physiology. Somerville, G. A. (ed.). Caister Academic Press, p. 221-248Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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PhD course "Infection Microbiology": time schedule for module A, 2010
Frees, Dorte, Nielsen, M. & Thomsen, Line Elnif, 2010, Department of Veterinary Disease Biology, University of Copenhagen. 72 p.Research output: Book/Report › Compendium/lecture notes › Education
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Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network
Frees, Dorte, Sørensen, K. & Ingmer, Hanne, 2005, In: Infection and Immunity. 73, 12, p. 8100-8108 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus
Frees, Dorte, Gerth, U. & Ingmer, Hanne, 2014, In: International Journal of Medical Microbiology. 304, 2, p. 142-149 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Finding New Fundamental Pieces for the Bacterial Cell Division Puzzle
Frees, Dorte & Ingmer, Hanne, 2022, In: mBio. 13, 4, e0073722.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial proteases and virulence
Frees, Dorte, Brøndsted, Lone & Ingmer, Hanne, 2013, Regulated proteolysis in microorganisms. Dougan, D. A. (ed.). Springer, p. 161-192 32 p. (Subcellular biochemistry, Vol. 66).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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A hitherto not recognized phenotype of spvA in Salmonella
Frees, Dorte, Gram, L., Holmstrøm, K. & Olsen, John Elmerdahl, 2010, Proceedings: 13S international symposium salmonella and salmonellosis. p. 33-34 2 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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Staphylococcus aureus ClpYQ plays a minor role in stress survival
Frees, Dorte, Thomsen, Line Elnif & Ingmer, Hanne, 2005, In: Archives of Microbiology. 183, 4, p. 286-291 6 p.Research output: Contribution to journal › Journal article › Research
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New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564
Frees, Dorte, Andersen, J. H., Hemmingsen, L., Koskenniemi, K., Bæk, K. T., Muhammed, Musemma Kedir, Gudeta, D. D., Nyman, T. A., Sukura, A., Varmanen, P. & Savijoki, K., 2012, In: Journal of Proteome Research. 11, 1, p. 95-108 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria
Frees, Dorte, Savijoki, K., Varmanen, P. & Ingmer, Hanne, 2007, In: Molecular Microbiology. 63, 5, p. 1285-1295 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of proteins induced at low pH in Lactococcus lactis
Frees, Dorte, Vogensen, Finn Kvist & Ingmer, Hanne, 2003, In: International Journal of Food Microbiology. 87, 87, p. 293-300 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Planktonic aggregates of Staphylococcus aureus protect against common antibiotics
Haaber, J. K., Cohn, M. T., Frees, Dorte, Andersen, Thorbjørn Joest & Ingmer, Hanne, 2012, In: P L o S One. 7, 7, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice
Harslund, J. L. F., Frees, Dorte, Leifsson, Páll S., Offenberg, H. K., Rømer, M. U. K., Brünner, N. & Olsen, John Elmerdahl, 2013, In: Pathogens and Disease. 68, 3, p. 96-104 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division
Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, Dorte, 2024, In: Molecular Microbiology. 121, 1, p. 98-115Research output: Contribution to journal › Journal article › Research › peer-review
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Salmonella isolates with different behavior in adhesion to surfaces studied by DNA micro array assisted analysis
Holmstrøm, K., Olsen, K. N., Meldgaard, H., Bagge-Ravn, D., Frees, Dorte, Lauritsen, D., Gram, L. & Olsen, John Elmerdahl, 2005. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
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Fødevaresikkerhed i udvikling
Ingmer, Hanne, Larsen, M. H., Leisner, Jørgen, Frees, Dorte, Brøndsted, Lone & Dalsgaard, Anders, 2019, In: Dansk Veterinaertidsskrift. 2019, 7, p. 10-13Research output: Contribution to journal › Journal article › Communication
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Identification of the ClpX Regulon in Staphylococcus aureus
Jelsbak, L., Thomsen, Line Elnif, Ingmer, Hanne, Donat, S., Ohlsen, K. & Frees, Dorte, 2006. 1 p.Research output: Contribution to conference › Poster › Research
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Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus
Jelsbak, L., Hemmingsen, L., Donat, S., Ohlsen, K., Boye, K., Westh, H., Ingmer, Hanne & Frees, Dorte, 2010, In: International Journal of Medical Microbiology. 300, 4, p. 229-236 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by rot dependent and independent pathways
Jelsbak, L., Ingmer, Hanne, Valihrach, L., Cohn, M. T., Christiansen, M. H. G., Kallipolitis, B. H. & Frees, Dorte, 2010, In: PLoS ONE. 5, 9, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis
Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, Lijuan, Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, Dorte, 2019, In: PLOS Pathogens. 15, 9, 27 p., e1008044.Research output: Contribution to journal › Journal article › Research › peer-review
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Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus
Jensen, C., Li, H., Vestergaard, M., Dalsgaard, Anders, Frees, Dorte & Leisner, Jørgen, 2020, In: Frontiers in Microbiology. 11, 8 p., 1007.Research output: Contribution to journal › Journal article › Research › peer-review
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Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, Dorte, 2019, In: Scientific Reports. 9, 11 p., 16456.Research output: Contribution to journal › Journal article › Research › peer-review
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A porcine model of heamatogenous osteomyelitis: pathogenesis and pathology
Jensen, Louise Kruse, Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Buelund, Lene Elisabeth, Svalastoga, Eiliv Lars & Jensen, Henrik Elvang, 2012. 1 p.Research output: Contribution to conference › Poster › Research
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Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis
Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study
Jensen, Louise Kruse, Frees, Dorte, Aalbæk, Bent, Koch, J., Iburg, T. M., Nielsen, O. L., Leifsson, Páll S. & Jensen, Henrik Elvang, 2011, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 119, 2, p. 111-118 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Therapy of haematogenous osteomyelitis: a comparative study in a porcine model and Angolan children
Jensen, Louise Kruse, Koch, J., Kirketerp-Møller, K., Wamsler, O. J., Nielsen, O. L., Leifsson, Páll S., Frees, Dorte, Aalbæk, Bent & Jensen, Henrik Elvang, 2013, In: In Vivo. 27, 3, p. 305-312 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis
Jensen, Louise Kruse, Iburg, T. M., Nielsen, O. L., Leifsson, Páll S., Dahl-Pedersen, Kirstin, Koch, J., Frees, Dorte, Aalbæk, Bent, Heegaard, P. M. H. & Jensen, Henrik Elvang, 2012, In: Prostaglandins & Other Lipid Mediators. 97, 3-4, p. 103-108 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri
Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte, Dalsgaard, I. & Jørgensen, Louise von Gersdorff, 12 Jul 2016, In: P L o S One. 11, 7, e0158968.Research output: Contribution to journal › Journal article › Research › peer-review
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Antigen uptake in zebrafish (Danio rerio) at different life stages
Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Jørgensen, Louise von Gersdorff, 2016.Research output: Contribution to conference › Conference abstract for conference › Research
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GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation
Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2010, In: Veterinary Research. 41, 25, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression and secretion of the RTX-toxin GtxA among members of the genus Gallibacterium
Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2011, In: Veterinary Microbiology. 153, 1-2, p. 116-123 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distribution, expression and secretion of the RTX-toxin GtxA among members of the genus Gallibacterium
Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2010, Pathogenesis of bacterial diseases in animals. p. 22 1 p.Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research
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Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
Larsen, J., Clasen, J., Hansen, J. E., Paulander, W., Petersen, A., Larsen, A. R. & Frees, Dorte, Jul 2016, In: Antimicrobial Agents and Chemotherapy. 60, 7, p. 4401-4403Research output: Contribution to journal › Journal article › Research › peer-review
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Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes
Mellergaard, M., Høgh, R. I., Feilberg, Astrid Lund, Aldana, Blanca, Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, Stine Dam, Hansen, Camilla Hartmann Friis, Andresen, Lars, Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, Helle S., Frees, Dorte & Skov, Søren, 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821Research output: Contribution to journal › Journal article › Research › peer-review
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Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor
Mellergaard, M., Skovbakke, S. L., Jepsen, S. D., Panagiotopoulou, N., Hansen, A. B. R., Tian, W., Lund, A., Høgh, R. I., Møller, S. H., Guérillot, R., Hayes, A. S., Erikstrup, L. T., Andresen, L., Peleg, A. Y., Larsen, A. R., Stinear, T. P., Handberg, A., Erikstrup, C., Howden, B. P., Goletz, S. & 2 others, , 2023, In: mBio. 14, 5, 21 p., e01349-23.Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid in vivo development of resistance to daptomycin in vancomycin-resistant Enterococcus faecium due to genomic alterations
Mollerup, S., Elmeskov, C., Pinholt, M., Sejersen, T. S., Pedersen, M. S., Worning, P., Frees, Dorte & Westh, Henrik T., 2022, In: FEMS Microbiology Letters. 369, 1, 6 p., 063.Research output: Contribution to journal › Journal article › Research › peer-review
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Method for screening compounds that influence virulence gene expression in Staphylococcus aureus
Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2010, In: Antimicrobial Agents and Chemotherapy. 54, 1, p. 509-512 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Simple plate assay for identification of new compounds used in anti-virulence therapy of Staphylococcus aureus
Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2008.Research output: Contribution to conference › Poster › Research
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Simple plate assay for identification of new compounds used in anti-virulence therapy of Staphylococcus aureus
Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2008. 1 p.Research output: Contribution to conference › Paper › Research › peer-review
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Solonamide B Inhibits Quorum Sensing and reduces Staphylococcus aureus mediated killing of Human Neutrophils
Nielsen, A., Månsson, M., Gram, L., Larsen, T. O., Phipps, R. K., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, Aug 2012.Research output: Contribution to conference › Poster › Research
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Norlichexanthone modulate Staphylococcus aureus virulence gene expression possibly via agr and sae
Nielsen, A., Ifrah, D., Friberg, C., Larsen, T. O., Novick, R. P., Frøkiær, Hanne, Frees, Dorte, Hede, N. G. & Ingmer, Hanne, 2012.Research output: Contribution to conference › Poster › Research
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Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils
Nielsen, A., Månsson, M., Bojer, Martin Saxtorph, Gram, L., Larsen, T. O., Novick, R. P., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, 2014, In: P L o S One. 9, 1, p. e84992 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Simple plate assay for identification of new compounds used in anti-virulence therapy of Staphylococcus aureus
Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2008.Research output: Contribution to conference › Poster › Research
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Searching for small sB-regulated genes in Staphylococcus aureus
Nielsen, J. S., Christiansen, M. H. G., Bonde, M., Gottschalk, S., Frees, Dorte, Thomsen, Line Elnif & Kallipolitis, B. H., 2011, In: Archives of Microbiology. 193, 1, p. 23-34 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study
Nielsen, O. L., Mellergaard, M., Frees, Dorte, Larsen, M. N., Skov, Søren, Olsen, Lisbeth Høier & Reimann, Maria Josefine, 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370Research output: Contribution to journal › Journal article › Research › peer-review
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A porcine subcutaneous Staphylococcus aureus abscess model - a pilot study
Nielsen, O. L., Larsen, M. N., Frees, Dorte, Pedersen, M. M., Skov, Søren & Olsen, Lisbeth Høier, 2017.Research output: Contribution to conference › Conference abstract for conference › Communication
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Investigation of correlation between gene expressions of 162 selected genes and survival and colonization abilities of Salmonella strains in the food chain
Olsen, John Elmerdahl, Gram, L., Frees, Dorte & Holmstrøm, K., 2008, The 21st International ICFMH Symposium "Evolving Microbial Food Quality and Safety": Programme and Abstract Book. p. 164 1 p.Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research
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Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool
Olsen, John Elmerdahl, Frees, Dorte, Kyvsgaard, N. C. & Barco, L., 2024, In: Letters in Applied Microbiology. 77, 2, 9 p., ovae015.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of Spi-6 and a putative type six secretion system in Salmonella serotype Gallinarum virulence
Olsen, John Elmerdahl, Kristensen, B. M. & Frees, Dorte, 2009, ASM conference on Salmonella: Biology, Pathogenesis & Prevention. p. 50 1 p.Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research
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Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus
Pamp, S. J., Frees, Dorte, Engelmann, S., Hecker, M. & Ingmer, Hanne, 2006, In: Journal of Bacteriology. 188, 13, p. 4861-4870 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus
Paulander, W. E. A., Varming, A. N., Bæk, K. T., Haaber, J. K., Frees, Dorte & Ingmer, Hanne, 2012, In: mBio. 3, 6, p. e00459-12 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of ClpX in Staphylococcus aureus stress response and virulence
Rasmussen, T., Frees, Dorte & Thomsen, Line Elnif, 2007. 1 p.Research output: Contribution to conference › Poster › Research
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Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP
Savijoki, K., Ingmer, Hanne, Frees, Dorte, Vogensen, Finn Kvist, Palva, A. & Varmanen, P., 2003, In: Molecular Microbiology. 50, 2, p. s.609-621 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec
Schelin, J., Cohn, M. T., Frisk, B. & Frees, Dorte, 2020, In: Toxins. 12, 9, 553.Research output: Contribution to journal › Journal article › Research › peer-review
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The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, Dorte, 2017, In: Scientific Reports. 7, 14 p., 11739.Research output: Contribution to journal › Journal article › Research › peer-review
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The sle1 cell wall amidase is essential for β-lactam resistance in community-acquired methicillin-resistant staphylococcus aureus USA300
Thalsø-Madsen, I., Torrubia, F. R., Xu, Lijuan, Petersen, A., Jensen, C. & Frees, Dorte, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 1, 15 p., e01931-19.Research output: Contribution to journal › Journal article › Research › peer-review
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SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis
Veiga, P., Bulbarela-Sampieri, C., Furlan, S., Maisons, A., Chapot-Chartier, M., Erkelenz, M., Mervelet, P., Noirot, P., Frees, Dorte, Kuipers, O. P., Kok, J., Gruss, A., Buist, G. & Kulakauskas, S., 2007, In: Journal of Biological Chemistry. 282, 27, p. 19342-19354 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibiotic Resistance and the MRSA Problem
Vestergaard, M., Frees, Dorte & Ingmer, Hanne, 2019, In: Microbiology Spectrum. 7, 2, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus
Villanueva, M., Jousselin, A., Baek, K. T., Prados, J., Andrey, D. O., Renzoni, A., Ingmer, Hanne, Frees, Dorte & Kelley, W. L., 1 Oct 2016, In: Journal of Bacteriology. 198, 19, p. 2719-2731 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology
Xu, Lijuan, Henriksen, C., Mebus, Viktor Hundtofte, Guérillot, R., Petersen, A., Jacques, N., Jiang, J. H., Derks, R. J. E., Sánchez-López, E., Giera, M., Leeten, K., Stinear, T. P., Oury, C., Howden, B. P., Peleg, A. Y. & Frees, Dorte, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4233088
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Planktonic aggregates of Staphylococcus aureus protect against common antibiotics
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The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by rot dependent and independent pathways
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The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
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