A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils
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A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils. / Wilson, S.; Jones, F. M.; Fofana, H. K. M.; Landouré, A.; Kimani, G.; Mwatha, J. K.; Sacko, M.; Vennervald, Birgitte J; Dunne, D. W.
I: Parasite Immunology, Bind 35, Nr. 7-8, 2013, s. 224-228.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils
AU - Wilson, S.
AU - Jones, F. M.
AU - Fofana, H. K. M.
AU - Landouré, A.
AU - Kimani, G.
AU - Mwatha, J. K.
AU - Sacko, M.
AU - Vennervald, Birgitte J
AU - Dunne, D. W.
N1 - © 2013 John Wiley & Sons Ltd.
PY - 2013
Y1 - 2013
N2 - IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.
AB - IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.
U2 - 10.1111/pim.12035
DO - 10.1111/pim.12035
M3 - Journal article
C2 - 23521712
VL - 35
SP - 224
EP - 228
JO - Parasite Immunology
JF - Parasite Immunology
SN - 0141-9838
IS - 7-8
ER -
ID: 65708156