An experimental model for iron deficiency anemia in sows and offspring induced by blood removal during gestation
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An experimental model for iron deficiency anemia in sows and offspring induced by blood removal during gestation. / Rydal, Martin Peter; Bhattarai, Sheeva; Nielsen, Jens Peter.
I: Animals, Bind 11, Nr. 10, 2848, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - An experimental model for iron deficiency anemia in sows and offspring induced by blood removal during gestation
AU - Rydal, Martin Peter
AU - Bhattarai, Sheeva
AU - Nielsen, Jens Peter
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Anemia is a common condition in sow herds. We aimed to study the effects of severe iron deficiency during gestation on sow and piglet health outcomes with an experimental model for blood-removal-induced iron deficiency anemia. In total, 18 multiparous sows (8 in trial I and 10 in trial II) were allocated to either a blood removal group or a control group. Hematologic parameters were monitored at regular intervals and the tissue iron concentrations were measured for the sows and newborn piglets after farrowing. In trial I, the mean liver iron content was reduced to 46.7 µg/g in the blood removal sows compared to 252.6 µg/g in the controls (p < 0.001). In trial II, sows in the blood removal group had lower iron content in the liver (147.8 µg/g), kidney (46.3 µg/g) and spleen (326.5 µg/g) compared to the control sows (323.2 µg/g, 81.3 µg/g and 728.9 µg/g, respectively; p = 0.009, 0.016, 0.01, respectively). In trial I, piglets from sows in the blood removal group had significantly decreased hematocrit (Hct), red blood cells (RBC) and a tendency for reduced hemoglobin (Hb) compared to the control piglets. We established a blood removal model that resulted in mild-to severe degrees of sow anemia and reduced tissue iron stores at farrowing.
AB - Anemia is a common condition in sow herds. We aimed to study the effects of severe iron deficiency during gestation on sow and piglet health outcomes with an experimental model for blood-removal-induced iron deficiency anemia. In total, 18 multiparous sows (8 in trial I and 10 in trial II) were allocated to either a blood removal group or a control group. Hematologic parameters were monitored at regular intervals and the tissue iron concentrations were measured for the sows and newborn piglets after farrowing. In trial I, the mean liver iron content was reduced to 46.7 µg/g in the blood removal sows compared to 252.6 µg/g in the controls (p < 0.001). In trial II, sows in the blood removal group had lower iron content in the liver (147.8 µg/g), kidney (46.3 µg/g) and spleen (326.5 µg/g) compared to the control sows (323.2 µg/g, 81.3 µg/g and 728.9 µg/g, respectively; p = 0.009, 0.016, 0.01, respectively). In trial I, piglets from sows in the blood removal group had significantly decreased hematocrit (Hct), red blood cells (RBC) and a tendency for reduced hemoglobin (Hb) compared to the control piglets. We established a blood removal model that resulted in mild-to severe degrees of sow anemia and reduced tissue iron stores at farrowing.
KW - Anemia model
KW - Erythrocyte indices
KW - Farrowing
KW - Piglet viability
KW - Pregnancy
KW - Stillbirth
KW - Swine
U2 - 10.3390/ani11102848
DO - 10.3390/ani11102848
M3 - Journal article
C2 - 34679868
AN - SCOPUS:85115957213
VL - 11
JO - Animals
JF - Animals
SN - 2076-2615
IS - 10
M1 - 2848
ER -
ID: 281605262