Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

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Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease. / Baldry, Mara; Nakamura, Yuumi; Nakagawa, Seitaro; Frees, Dorte; Matsue, Hiroyuki; Nunez, Gabriel; Ingmer, Hanne.

I: Journal of Infectious Diseases, Bind 218, Nr. 6, 2018, s. 1009-1013.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Baldry, M, Nakamura, Y, Nakagawa, S, Frees, D, Matsue, H, Nunez, G & Ingmer, H 2018, 'Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease', Journal of Infectious Diseases, bind 218, nr. 6, s. 1009-1013. https://doi.org/10.1093/infdis/jiy259

APA

Baldry, M., Nakamura, Y., Nakagawa, S., Frees, D., Matsue, H., Nunez, G., & Ingmer, H. (2018). Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease. Journal of Infectious Diseases, 218(6), 1009-1013. https://doi.org/10.1093/infdis/jiy259

Vancouver

Baldry M, Nakamura Y, Nakagawa S, Frees D, Matsue H, Nunez G o.a. Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease. Journal of Infectious Diseases. 2018;218(6):1009-1013. https://doi.org/10.1093/infdis/jiy259

Author

Baldry, Mara ; Nakamura, Yuumi ; Nakagawa, Seitaro ; Frees, Dorte ; Matsue, Hiroyuki ; Nunez, Gabriel ; Ingmer, Hanne. / Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease. I: Journal of Infectious Diseases. 2018 ; Bind 218, Nr. 6. s. 1009-1013.

Bibtex

@article{d5cdf7987c594c68b9b2c5edffaf9f18,
title = "Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease",
abstract = "Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus δ-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. δ-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished δ-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders.",
keywords = "Staphylococcus aureus, agr quorum sensing inhibition, atopic dermatitis, delta-toxin, antivirulence therapy",
author = "Mara Baldry and Yuumi Nakamura and Seitaro Nakagawa and Dorte Frees and Hiroyuki Matsue and Gabriel Nunez and Hanne Ingmer",
year = "2018",
doi = "10.1093/infdis/jiy259",
language = "English",
volume = "218",
pages = "1009--1013",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

AU - Baldry, Mara

AU - Nakamura, Yuumi

AU - Nakagawa, Seitaro

AU - Frees, Dorte

AU - Matsue, Hiroyuki

AU - Nunez, Gabriel

AU - Ingmer, Hanne

PY - 2018

Y1 - 2018

N2 - Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus δ-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. δ-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished δ-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders.

AB - Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus δ-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. δ-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished δ-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders.

KW - Staphylococcus aureus

KW - agr quorum sensing inhibition

KW - atopic dermatitis

KW - delta-toxin

KW - antivirulence therapy

U2 - 10.1093/infdis/jiy259

DO - 10.1093/infdis/jiy259

M3 - Journal article

C2 - 29733353

VL - 218

SP - 1009

EP - 1013

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -

ID: 202979987