Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies

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Standard

Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies. / Hägglund, Sara; Hu, Ke Fei; Larsen, Lars Erik; Hakhverdyan, Mikhayil; Valarcher, Jean François; Taylor, Geraldine; Morein, Bror; Belák, Sándor; Alenius, Stefan.

I: Vaccine, Bind 23, Nr. 5, 16.12.2004, s. 646-655.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hägglund, S, Hu, KF, Larsen, LE, Hakhverdyan, M, Valarcher, JF, Taylor, G, Morein, B, Belák, S & Alenius, S 2004, 'Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies', Vaccine, bind 23, nr. 5, s. 646-655. https://doi.org/10.1016/j.vaccine.2004.07.006

APA

Hägglund, S., Hu, K. F., Larsen, L. E., Hakhverdyan, M., Valarcher, J. F., Taylor, G., Morein, B., Belák, S., & Alenius, S. (2004). Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies. Vaccine, 23(5), 646-655. https://doi.org/10.1016/j.vaccine.2004.07.006

Vancouver

Hägglund S, Hu KF, Larsen LE, Hakhverdyan M, Valarcher JF, Taylor G o.a. Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies. Vaccine. 2004 dec. 16;23(5):646-655. https://doi.org/10.1016/j.vaccine.2004.07.006

Author

Hägglund, Sara ; Hu, Ke Fei ; Larsen, Lars Erik ; Hakhverdyan, Mikhayil ; Valarcher, Jean François ; Taylor, Geraldine ; Morein, Bror ; Belák, Sándor ; Alenius, Stefan. / Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies. I: Vaccine. 2004 ; Bind 23, Nr. 5. s. 646-655.

Bibtex

@article{971bdc85a044494ea5cb886ae45f9c3c,
title = "Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies",
abstract = "The protection induced by immunostimulating complexes (ISCOMs) against bovine respiratory syncytial virus (BRSV) was evaluated and compared to that of a commercial inactivated vaccine (CV) in calves with BRSV-specific maternal antibodies. Following experimental challenge, controls (n = 4) and animals immunized with CV (n = 5) developed moderate to severe respiratory disease, whereas calves immunized with ISCOMs (n = 5) remained clinically healthy. BRSV was re-isolated from the nasopharynx of all controls and from all calves immunized with CV, but from none of the calves immunized with ISCOMs. BRSV-RNA was detected by real-time PCR from a single animal in this group. Significantly higher BRSV-specific nasal IgG, serum IgG 1 and IgG 2 titers were detected before and after challenge in animals immunized with ISCOMs versus CV. In conclusion, the ISCOMs overcame the suppressive effect of maternal antibodies in calves and induced strong clinical and virological protection against a BRSV challenge.",
keywords = "Bovine respiratory syncytial virus, BRSV, ISCOM",
author = "Sara H{\"a}gglund and Hu, {Ke Fei} and Larsen, {Lars Erik} and Mikhayil Hakhverdyan and Valarcher, {Jean Fran{\c c}ois} and Geraldine Taylor and Bror Morein and S{\'a}ndor Bel{\'a}k and Stefan Alenius",
year = "2004",
month = dec,
day = "16",
doi = "10.1016/j.vaccine.2004.07.006",
language = "English",
volume = "23",
pages = "646--655",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Bovine respiratory syncytial virus ISCOMs - Protection in the presence of maternal antibodies

AU - Hägglund, Sara

AU - Hu, Ke Fei

AU - Larsen, Lars Erik

AU - Hakhverdyan, Mikhayil

AU - Valarcher, Jean François

AU - Taylor, Geraldine

AU - Morein, Bror

AU - Belák, Sándor

AU - Alenius, Stefan

PY - 2004/12/16

Y1 - 2004/12/16

N2 - The protection induced by immunostimulating complexes (ISCOMs) against bovine respiratory syncytial virus (BRSV) was evaluated and compared to that of a commercial inactivated vaccine (CV) in calves with BRSV-specific maternal antibodies. Following experimental challenge, controls (n = 4) and animals immunized with CV (n = 5) developed moderate to severe respiratory disease, whereas calves immunized with ISCOMs (n = 5) remained clinically healthy. BRSV was re-isolated from the nasopharynx of all controls and from all calves immunized with CV, but from none of the calves immunized with ISCOMs. BRSV-RNA was detected by real-time PCR from a single animal in this group. Significantly higher BRSV-specific nasal IgG, serum IgG 1 and IgG 2 titers were detected before and after challenge in animals immunized with ISCOMs versus CV. In conclusion, the ISCOMs overcame the suppressive effect of maternal antibodies in calves and induced strong clinical and virological protection against a BRSV challenge.

AB - The protection induced by immunostimulating complexes (ISCOMs) against bovine respiratory syncytial virus (BRSV) was evaluated and compared to that of a commercial inactivated vaccine (CV) in calves with BRSV-specific maternal antibodies. Following experimental challenge, controls (n = 4) and animals immunized with CV (n = 5) developed moderate to severe respiratory disease, whereas calves immunized with ISCOMs (n = 5) remained clinically healthy. BRSV was re-isolated from the nasopharynx of all controls and from all calves immunized with CV, but from none of the calves immunized with ISCOMs. BRSV-RNA was detected by real-time PCR from a single animal in this group. Significantly higher BRSV-specific nasal IgG, serum IgG 1 and IgG 2 titers were detected before and after challenge in animals immunized with ISCOMs versus CV. In conclusion, the ISCOMs overcame the suppressive effect of maternal antibodies in calves and induced strong clinical and virological protection against a BRSV challenge.

KW - Bovine respiratory syncytial virus

KW - BRSV

KW - ISCOM

U2 - 10.1016/j.vaccine.2004.07.006

DO - 10.1016/j.vaccine.2004.07.006

M3 - Journal article

C2 - 15542185

AN - SCOPUS:8144222958

VL - 23

SP - 646

EP - 655

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 5

ER -

ID: 247400644