Breed differences in natriuretic peptides in healthy dogs
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Breed differences in natriuretic peptides in healthy dogs. / Sjöstrand, K.; Wess, G.; Ljungvall, I.; Häggström, J.; Merveille, A.-C.; Wiberg, M.; Gouni, V.; Willesen, Jakob; Hanås, S.; Lequarré, A.-S.; Sørensen, L. Mejer; Wolf, J.; Tiret, L; Kierczak, M.; Forsberg, S.; McEntee, K.; Battaille, G.; Seppälä, E.; Lindblad-Toh, K.; Georges, M.; Lohi, Hannes; Chetboul, V.; Fredholm, Merete; Höglund, K.
I: Journal of Veterinary Internal Medicine, Bind 28, Nr. 2, 2014, s. 451-457.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Breed differences in natriuretic peptides in healthy dogs
AU - Sjöstrand, K.
AU - Wess, G.
AU - Ljungvall, I.
AU - Häggström, J.
AU - Merveille, A.-C.
AU - Wiberg, M.
AU - Gouni, V.
AU - Willesen, Jakob
AU - Hanås, S.
AU - Lequarré, A.-S.
AU - Sørensen, L. Mejer
AU - Wolf, J.
AU - Tiret, L
AU - Kierczak, M.
AU - Forsberg, S.
AU - McEntee, K.
AU - Battaille, G.
AU - Seppälä, E.
AU - Lindblad-Toh, K.
AU - Georges, M.
AU - Lohi, Hannes
AU - Chetboul, V.
AU - Fredholm, Merete
AU - Höglund, K.
N1 - Copyright © 2014 by the American College of Veterinary Internal Medicine.
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor.OBJECTIVE: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs.ANIMALS: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project.METHODS: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays.RESULTS: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers.CONCLUSIONS AND CLINICAL IMPORTANCE: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.
AB - BACKGROUND: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor.OBJECTIVE: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs.ANIMALS: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project.METHODS: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays.RESULTS: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers.CONCLUSIONS AND CLINICAL IMPORTANCE: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.
U2 - 10.1111/jvim.12310
DO - 10.1111/jvim.12310
M3 - Journal article
C2 - 24495256
VL - 28
SP - 451
EP - 457
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 2
ER -
ID: 120893524